A leaf spot of field corn was shown to be caused by the bacterium Pseudomonas andropogonis. Leaf spot symptoms were observed over 3 years in several States. Inoculation of corn by vacuum infiltration of the bacteria was necessary to reproduce field symptoms. Plant Dis. Reptr. 62: 213-216. A bacterial leaf spot disease of different cultivars of field corn was observed in early summer of 1973, 19...

Background: Acalabrutinib (A) is a next-generation Bruton tyrosine kinase inhibitor approved for relapsed/refractory (R/R) mantle cell lymphoma (MCL). Bendamustine (B) + rituximab (R) used treatment-naive (TN) and R/R MCL. We present updated ABR safety efficacy data in patients (pts) with TN or Methods: Eligible adults received (phase 1b; NCT02717624) as follows: 6 28-d cycles, maintenance A+R ...

We have studied the accumulation of peptidyl hydroxyproline in the pericarp of developing maize (Zea mays L., Golden cross Bantam sweet corn) kernels. Although this hydroxyproline accumulates throughout development, it is most soluble and its content per milligram dry weight greatest at midmaturation stages of development. Salt-soluble proteins containing this hydroxyproline from isolated cell ...

Three laboratories previously have obtained from Zea mays kernels (milk stage) one or more 6-(substituted)aminopurines capable of greatly promoting cell division in plant tissue cultures.1-3 At least two of the laboratories have worked on a single compound4 which has been identified as 6-(4-hydroxy-3-methylbut-2-enyl)aminopurine.5 The name zeatin has been applied to this particular compound.6 O...

In the data-mining field, many learning methods — such as association rules, Bayesian networks, and induction rules (Grzymala-Busse & Stefanowski, 2001) — can handle only discrete attributes. Therefore, before the machine-learning process, it is necessary to re-encode each continuous attribute in a discrete attribute constituted by a set of intervals. For example, the age attribute can be trans...

Introduction: Patients (pts) with R/R MCL after ≥2 prior lines of therapy, including Bruton tyrosine kinase inhibitor (BTKi), have a poor prognosis. Liso-cel is an autologous, CD19-directed, CAR T cell product administered at equal target doses CD8+ and CD4+ CAR+ cells. The phase 1, seamless design, dose-finding TRANSCEND NHL 001 study (NCT02631044) evaluated liso-cel in pts NHL. Here we report...

Recognition, acknowledgment, and acceptance of biases in a nonjudgmental manner is key to advancing knowledge avoiding biased behaviors. Unconscious do not mean people are bad, they those who raised or educated us bad people. They lessons were learned that unconsciously affect decision-making. Awareness management implicit bias critical successful growth as diverse, equitable, inclusive teams. ...

This chapter introduces the theme of the book (i.e., the challenge of chance) and includes brief surveys of the individual chapters. The collapse of cohesion is one of the features that characterize chance. By sheer accident, or so it seems, something breaks the typical regularity of the natural world, like a comet disrupting the solar system. At a human scale, we find examples like unexpectedl...

It does not happen often that an entirely novel gene regulatory mechanism is revealed. The discovery of microRNAs (miRNAs) is one such finding that revolutionized our understanding of cellular events and of the intricacy of developmental processes [1,2]. These small (,22 nucleotide), single-stranded RNA molecules act through binding in a sequence-specific manner to the 39UTR of mRNA targets, an...

Precision in spatial and temporal control of gene expression is important for formation of tissues and organs. Roughly 5% of the known gene complement in animals encodes transcriptional activators and repressors, whose combinatorial action controls the expression of target genes, triggering cell-fate decisions and differentiation during development. With the discovery of microRNAs, a new means ...