This paper deals with the evaluation of lipophilicity expressed by logPow parameter ten barbiturate derivatives generally used as sedative-hypnotics based on Density Functional Theory (DFT) calculations. All geometry optimizations and frequency calculations have been carried out using DFT/B3LYP/ 6-311++G (d,p) basis set in gas phase also water n-octanol phases. Gibbs free energies solvation for...

This paper reports an Australian trial of the British Army Recruit Battery (BARB), an innovative set of computer administered tests designed to provide measures of cognitive abilities. The trial was made possible because Australia, along with Canada, New Zealand, the United Kingdom and the United States of America participate in a non-atomic military research agreement called The Technical Coop...

Four hundred and seventy-two cases of poisoning were seen over a two-year period in Kandy, Ceylon. The overall mortality was 23 7 %. The pattern of poisoning was different from that in western countries in that 49 8 % of the cases weie due to insecticide poisoning and only 10 7 % were due to drugs, including barbiturates. Insecticides accounted for 73.2% and drugs for only 4 5% of the 112 fatal...