It is known that the interleukin-4 receptor α (IL-4R α ) is highly expressed on the surface of various human solid tumors. We previously designed novel IL-4R α -lytic hybrid peptide composed of binding peptide to IL-4R α and cell-lytic peptide and reported that the designed IL-4R α -lytic hybrid peptide exhibited cytotoxic and antitumor activity both in vitro and in vivo against the human pancr...

Heparin-binding epidermal growth factor (HB-EGF) and betacellulin (BTC) are activating ligands for EGF receptor (EGFR/ErbB1) and ErbB4. To identify their physiological functions, we disrupted mouse HB-EGF and BTC alleles by homologous recombination. Most HB-EGF(-/-) mice died before weaning, and survivors had enlarged, dysfunctional hearts and reduced lifespans. Although BTC(-/-) mice were viab...

BACKGROUND Unresectable biliary tract carcinoma (BTC) is associated with a very poor prognosis. To improve efficacy and tolerance of the 5-fluorouracil (5-FU)/cisplatin combination in BTC, we designed a new therapeutic schedule, the LV5FU2-P regimen. PATIENTS AND METHODS Twenty-nine patients with advanced or metastatic BTC were prospectively enrolled in the study. The treatment (LV5FU2-P regi...

BACKGROUND AND PURPOSE Systemic inflammation is known to promote carcinogenesis in biliary tract cancer (BTC). Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are indicative of systemic inflammation. We evaluated the clinical significance of systemic inflammation measured by NLR and PLR in patients with advanced BTC. Additionally, we also co-analyzed the dynamics of ...

Biliary tract cancer (BTC) is a group of relatively rare tumors with a poor prognosis. The current standard of care consists of doublet chemotherapy (platinum plus gemcitabine); however, even with cytotoxic therapy, the median overall survival is less than 1 year. The genetic basis of BTC is now more clearly understood, allowing for the investigation of targeted therapy. Combinations of doublet...

Hydro-thermal reaction involving zinc nitrate hexa-hydrate, tris-odium benzene-1,3,5-tricarboxyl-ate (Na(3)BTC) and 2-methyl-imidazole (2-MeImH) yielded the title compound, [Zn(2)(C(9)H(3)O(6))(C(4)H(5)N(2))(C(4)H(6)N(2))(3)]. In this mixed-ligand metal-organic compound, Zn(2+) ions are coordinated by N atoms from 2-MeImH mol-ecules and (2-MeIm)(-) ions, as well as by O atoms from (BTC)(3-) ion...

The results of empirical analyses confirm that analysed unsystematic factors, the Stock-to-Flow index (S2F), and information on Bitcoin (BTC) are directly correlated with BTC values. These expected in line economic theory; however, this research paper aimed to investigate impact factors value decentralised virtual cryptocurrency BTC. Its aim was also analyse reasons for significant oscillations...

In this paper we have proposed three and two stage still gray scale image compressor based on BTC. In our schemes, we have employed a combination of four techniques to reduce the bit rate. They are quad tree segmentation, bit plane omission, bit plane coding using 32 visual patterns and interpolative bit plane coding. The experimental results show that the proposed schemes achieve an average bi...

—This article presents an FPGA implementation of an ultra-high-speed Reed-Solomon (RS) turbo decoder. A performance analysis is performed showing that RS Block Turbo Codes (RS-BTC) have decoding performance equivalent to Bose Ray-Chaudhuri Hocquenghem-Block Turbo Codes (BCH-BTC). A ratio between the decoder throughput and the decoder area is used to show the higher ef ciency of the RS full para...

copper oxide nanostructures have been successfully synthesized via one-step solid-state thermolysis of two metal-organic frameworks, [cu3(btc)2] (1) and [cu(tpa).(dmf)] (2), (btc = benzene-1,3,5-tricarboxylate, tpa = therephtalic acid = 1,4-benzendicarboxylic acid and dmf = dimethyl formamide) under air atmosphere at 400,  500, and 600°c. it has also been found that the reaction temperature pla...