The mitochondrial outer membrane harbors two protein translocases that are essential for cell viability: the translocase of the outer mitochondrial membrane (TOM) and the sorting and assembly machinery (SAM). The precursors of β-barrel proteins use both translocases-TOM for import to the intermembrane space and SAM for export into the outer membrane. It is unknown if the translocases cooperate ...

Abstract. As part of a comprehensive survey and modelling project involving the Aachen Cathedral, this paper focuses on its oldest part, Palatine Chapel, domed octagonal hall supported by eight piers enveloped sixteen-sided outer wall. Working data collected during an extensive 3D capturing campaign conducted between 2022 2023, will focus conic vaults covering ambulacrum 1st floor that represen...

The seismic analysis of historical and monumental masonry buildings, especially churches cathedrals, is challenging expensive. These difficulties are mainly related to complex geometry the mechanical modelling historic structures. This paper aims show methodological approach evaluate vulnerability Masonry Cathedrals by analysis. numerical finite element model, modelled with solid elements, was ...

In rodents, each mystacial whisker is represented in the granular layer of primary somatosensory (SI) cortex by a compact cluster of cells known as a barrel, and barrels are separated from each other by domains that are called septa. Vertical columns of neurons aligned with each barrel act as a functional assembly to process information from a "principal" whisker, but a functional role has not ...

‘thesource base consists of total currency outstanding (held by the public and in the vaults of depository institutions) plus the reserve balances of depository institutions at Federal Reserve Banks. The level of the money stock (currency in the hands of the public plus checkable deposits) that can be supported with a given level of the source base depends on resen’e requirements. If required r...

BAM is a conserved molecular machine, the central component of which is BamA. Orthologues of BamA are found in all Gram-negative bacteria, chloroplasts and mitochondria where it is required for the folding and insertion of β-barrel containing integral outer membrane proteins (OMPs) into the outer membrane. BamA binds unfolded β-barrel precursors via the five polypeptide transport-associated (PO...

BACKGROUND The rodent barrel cortex is a widely used model to study the cortical processing of tactile sensory information. It is notable by the cytoarchitecture of its layer IV, which contains distinguishable structural units called barrels that can be considered as anatomical landmarks of the functional columnar organization of the cerebral cortex. To study sensory integration in the barrel c...

Understanding the molecular mechanisms underlying the formation of selective intracortical circuitry is one of the important questions in neuroscience research. "Barrel nets" are recently identified intracortical axonal trajectories derived from layer 2/3 neurons in layer 4 of the primary somatosensory (barrel) cortex. Axons of layer 2/3 neurons are preferentially distributed in the septal regi...

A distribution of dendrites was studied in mouse barrel field after a neonatal unilateral partial lesion of vibrissal follicles using anti-MAP-2 immunohistochemistry. The effect of a neonatal vibrissal follicles removal was studied in adult mice: barrels corresponding to intact follicles were enlarged whereas those representing removed follicles had not developed. MAP-2 immunopositive profiles ...

β-Barrel outer membrane proteins (OMPs) are found in the outer membranes of Gram-negative bacteria and are essential for nutrient import, signaling, and adhesion. A 200-kilodalton five-component complex called the β-barrel assembly machinery (BAM) complex has been implicated in the biogenesis of OMPs. We report the structure of the BAM complex from Escherichia coli, revealing that binding of Ba...