Debate about the relative roles of catastrophic v. continuous processes of landform evolution is as old as the discipline of Earth Science itself. Over the last 10 years or so, research in the Earth Sciences has focussed strongly on the Earth’s surface and particularly in terms of quantifying rates of processes. This research parallels developments in geomorphology and sedimentology in the quan...

the study area, paykola anticline, is located in the southwestern part of kermanshah province. the aim of this research is to evaluate the geomorphological indexes of active tectonics in paykola anticline as well as to study the effect of tectonic in the form and direction of geomorphological landforms. to achieve the aim of study, the lithological and tectonic characteristics of study area wer...

Geomorphic parameters are very helpful as they can quickly explain the concerned area, which is going through a tectonic adjustment. For this purpose, four indices were applied to examine active tectonics in Quetta-Ziarat region. These include: sub-basins asymmetry (Af), transverse topography (T-Factor), hypsometric integral (HI) and stream-length gradient (SL). The calculation of three denoted...

Hepatocyte growth factor (HGF) is a pulmotrophic factor for the regeneration of injured pulmonary tissue. We investigated the role of HGF in basement membrane formation during wound healing by immortalized alveolar type II epithelial cells that could form a continuous basement membrane when they were cultured on collagen fibrils in the presence of entactin-contaminated laminin-1. Cells cultured...

To metastasize, cancer cells must acquire the ability to breach several basement membrane barriers. Cell invasions through basement membranes also occur during normal development and immune system function, enabling organ formation and cell dispersal. The mechanisms that cells use to cross basement membranes in vivo remain elusive. In cancer and development, these invasions occur in complex and...

Several alphaherpesviruses breach the basement membrane during mucosal invasion. In the present study, the role of proteases in this process was examined. The serine protease-specific inhibitor AEBSF inhibited penetration of the basement membrane by the porcine alphaherpesvirus pseudorabies virus (PRV) by 88.1% without affecting lateral spread. Inhibitors of aspartic-, cysteine-, and metallopro...

Our recent studies revealed that focal basal cell layer disruption (FBCLD) induced auto-immunoreactions represented a contributing factor for human prostate tumor progression and invasion. As the basement membrane surrounds and attaches to the basal cell layer, our current study assessed whether FBCLD would impact the physical integrity of the associated basement membrane. Paraffin sections fro...

Recent research suggests that the basement membrane at the dermal-epidermal junction of the skin plays an important role in maintaining a healthy epidermis and dermis, and repeated damage to the skin can destabilize the skin and accelerate the aging process. Skin-equivalent models are suitable for studying the reconstruction of the basement membrane and its contribution to epidermal homeostasis...