To monitor a batch process, which is dynamic in nature, it is necessary to consider the time varying relationship of its variables throughout the entire run. MPCA models built with batch wise unfolded data have been used extensively for batch process monitoring, these methods will not only consider the known samples to asses the ongoing batch run, but will also consider a dynamic forecast of th...

This paper presents a new measurement-based optimization framework for batch processes whereby optimal operation can be achieved via the tracking of active constraints. It is shown that, under mild assumptions and to a first-order approximation, tracking the necessary conditions of optimality is equivalent to tracking active constraints (both during the batch and at the end of the batch). Thus ...

Glass-ceramic macroporous scaffolds were prepared using glass powders and polyethylene (PE) particles of two different sizes. The starting glass, named as Fa-GC, belongs to the system SiO(2)-P(2)O(5)-CaO-MgO-Na(2)O-K(2)O-CaF(2) and was synthesized by a traditional melting-quenching route. The glass was ground and sieved to obtain powders of specific size which were mixed with PE particles and t...

OBJECTIVES This work aimed to evaluate the performance of nanoparticle-loaded films based on matrices of polymethacrylates and hydroxypropylmethylcellulose (HPMC) intended for delivery of macromolecules. METHODS Lysozyme (Lys)-loaded nanoparticles were manufactured by antisolvent co-precipitation. After size, loading efficiency and stability characterization, the selected batch of particles w...

Dynamics are inherent characteristics of batch processes, and they may exist not only within a particular batch, but also from batch to batch. To model and monitor such two-dimensional (2D) batch dynamics, two-dimensional dynamic principal component analysis (2D-DPCA) has been developed. However, the original 2D-DPCA calculates the monitoring control limits based on the multivariate Gaussian di...

This paper integrates a cost reduction delivery policy into an imperfect production system with repairable items for the purpose of lowering producer’s stock holding cost. The present paper reexamines a manufacturing lot-size problem studied by a prior paper, and improves its production batch size solution in terms of lowering its inventory holding cost. An n+1 delivery policy is proposed here ...

Degradable microparticles have broad utility as vehicles for drug delivery and form the basis of several therapies approved by the US Food and Drug Administration. Conventional emulsion-based methods of manufacturing produce particles with a wide range of diameters (and thus kinetics of release) in each batch. This paper describes the fabrication of monodisperse, drug-loaded microparticles from...

Computational grids with multiple batch systems (batch grids) can be powerful infrastructures for executing long-running multi-component parallel applications. In this paper, we evaluate the potential improvements in throughput of long-running multi-component applications when the different components of the applications are executed on multiple batch systems of batch grids. We compare the mult...