Most large-scale production processes in biotechnology are performed in fed-batch operational mode. In contrast, the screenings for microbial production strains are run in batch mode, which results in the microorganisms being subjected to different physiological conditions. This significantly affects strain selection. To demonstrate differences in ranking during strain selection depending on th...

Ferritin is a macromolecule and is responsible for the long term iron storage function in human serum and plasma. Recent studies have highlighted the role of cell phone exposure on central nervous system, immune function and reproduction. The aim of this study was to investigate whether the human serum ferritin level could be interfered by the exposure to the 900 MHz GSM cell phones. Fifty huma...

Multiway principal component analysis (MPCA) for the analysis and monitoring of batch processes has recently been proposed. Although MPCA has found wide applications in batch process monitoring, it assumes that future batches behave in the same way as those used for model identification. In this study, a new monitoring algorithm, adaptive multiblock MPCA, is developed. The method overcomes the ...

High dietary nitrate and nitrite intake may increase the risk of gastro-intestinal cancers due to the In vivo formation of carcinogenic chemicals known as N-nitroso compounds. In this study nitrate and nitrite residues in smoked Caspian kutum, Rutilus frisii kutum and mullet, liza auratus in the local markets (considered as batch no. 1, 2 and 3) of north of Iran were determined using Spectropho...

mathematical modeling and simulation of microbial polyhydroxybutyrate (phb) production process is beneficial for optimization, design, and control purposes. in this study a batch model developed by mulchandani et al., [1] was used to simulate the process in matlab environment. it was revealed that the kinetic model parameters were estimated off the optimal or at a local optimal point. therefore...

To increase cell concentration and the production of alkaline protease, fed-batch cultures with standard medium (1x) or concentrated medium (2x or 5x) as feed were performed. In a fed-batch culture with standard medium as feed, the biomass concentration reached 9.6 g L–1 and the protease activity obtained was 8500 U mL–1 compared to 3000 U mL–1 obtained by growing Teredinobacter turnirae cells ...

An unconventional modelling methodology based on artificial neural networks is proposed to rapidly develop a model from data obtained during different batch experiments. The objective of the global predict time evolution concentrations all species present in reaction medium. For this, recurrent are elaborated estimate particular as function operating parameters and then assembled complex model....