Assisted reproductive technologies (ART) are the treatment of choice for some infertile couples and even though these procedures generally considered safe, children conceived by ART have shown higher reported risks perinatal postnatal complications such as low birth weight, preterm birth, childhood cancer. In addition, frequency congenital imprinting disorders, like Beckwith–Wiedemann Syndrome ...

p57(KIP2) is an imprinted gene located at the chromosomal locus 11p15.5. It is a cyclin-dependent kinase inhibitor belonging to the CIP/KIP family, which includes additionally p21(CIP1/WAF1) and p27(KIP1). It is the least studied CIP/KIP member and has a unique role in embryogenesis. p57(KIP2) regulates the cell cycle, although novel functions have been attributed to this protein including cyto...

Gene imprinting has conduited the scope of our understanding of phenotypic expression and its corelation with constituent genotype. It is an epigenetic process that involves DNA methylation and histone modulation to attain monoallelic gene expression without altering the genetic sequences. A distinctive model of non-mendelian genetics, imprinting extends the control over expression of traits an...