The title compound, C(28)H(34)Cl(2)O(7), is a derivative of the glucocorticoid steroid beclomethasone dipropionate. It features an expoxide linkage [angle at oxygen = 96.6 (2)°]. The dichlorocyclohexenone ring adopts an envelope conformation, with the C atom bearing the two Cl substituents representing the flap. The dichloro-methyl C atom deviates by 0.471 (4) Å from the plane defined by the ot...

BACKGROUND The therapeutic effect of inhaled corticosteroids (ICS) may be affected by the metabolism of the drug in the target organ. We investigated the in vitro metabolism of beclomethasone dipropionate (BDP), budesonide (BUD), ciclesonide (CIC), and fluticasone propionate (FP) in human lung precision-cut tissue slices. CIC, a new generation ICS, is hydrolyzed by esterases in the upper and lo...

BACKGROUND It has been reported that intranasal corticosteroids can influence bronchial hyperresponsiveness (BHR) in asthmatic subjects with seasonal rhinitis. The purpose of the present study was to evaluate the effect of intranasal fluticasone propionate and beclomethasone dipropionate on BHR and bronchial calibre (forced expiratory volume in one second, FEV(1)) in children and young adults w...

BACKGROUND Ciclesonide is a new inhaled corticosteroids licensed for the prophylactic treatment of persistent asthma in adults. Currently beclomethasone dipropionate, budesonide and fluticasone propionate are the most commonly prescribed inhaled corticosteroids for the treatment of asthma but there has been no systematic review comparing the effectiveness and safety ciclesonide to these agents....

STUDY OBJECTIVE One week of regular treatment with salmeterol can induce tolerance to the protective effect of a beta2-agonist on early airway response to allergen (EAR). The objective was to assess whether inhaled corticosteroids revert tolerance to salmeterol. STUDY DESIGN The study had a randomized, double-blind, placebo-controlled design. PATIENTS AND METHODS Twelve subjects with mild a...

The commercially available inhaled corticosteroids (ICS) for asthma treatment are beclomethasone dipropionate (BDP), budesonide (BUD), ̄unisolide (FLU), ̄uticasone propionate (FP), mometasone furoate (MF), and triamcinolone acetonide (TA); most of them are also available as nasal sprays for the treatment of rhinitis. There is no longer any doubt of their effectiveness in both asthma and rhinitis....

Buhl R, Soler M, Matz J, et al. Eur Respir J. 2002;20:73–78 Purpose of the Study. To examine the ability of omalizumab, an anti-immunoglobulin E (anti-IgE) agent, to maintain long-term disease control in patients with moderate-to-severe allergic asthma. Study Population. Four hundred eighty-three patients with moderate-to-severe allergic asthma maintained on beclomethasone diproprionate. Method...

infusion suggesting that, though the oesophageal mucosa might have been stimulated, the pain produced was not epigastric. We could not confirm that the cardiac sphincter pressure of those patients with epigastric pain was different from those without such pain. Moreover, radiological evidence of the capacity to herniate stomach, or of reflux of barium, as a measure of the incompetence of the an...

BACKGROUND The safety of high dose inhaled steroids has been a subject of debate. The efficacy and safety of beclomethasone dipropionate and budesonide inhalations were evaluated by measuring their effects on pulmonary function, on the hypothalamic-pituitary-adrenocortical axis, and on carbohydrate metabolism in adults with unstable asthma. METHODS Fifteen adults with unstable asthma and 15 h...