Introduction Inflammasomes are cytosolic multi-component signaling platforms critical to the innate immune response infectious diseases and dysregulation of their activation can lead development neurodegeneration cancer. Objectives We aim through this review ass a possible interplay between inflammasome activation, chronic inflammatory disease enhancement behavioral abnormalities. Methods compr...

BACKGROUND Major depressive disorder is highly prevalent among Latinos with limited English language proficiency in the United States. Although major depressive disorder is highly treatable, barriers to depression treatment have historically prevented Latinos with limited English language proficiency from accessing effective interventions. The project seeks to evaluate the efficacy of behaviora...

BACKGROUND Cognitive behavioral and related therapies for cocaine dependence may exert their effects, in part, by enhancing cognitive control over drug use behavior. No prior studies have systematically examined the neural correlates of cognitive control as related to treatment outcomes for cocaine dependence. METHODS Twenty treatment-seeking cocaine-dependent individuals performed a Stroop c...

The locus coeruleus–noradrenergic system exerts an activating influence on forebrain neuronal and behavioral activity states. For example, in the anesthetized rat, unilateral locus coeruleus stimulation elicits bilateral activation of forebrain electroencephalographic activity. Pretreatment with a noradrenergic b-antagonist blocks this effect, suggesting that b-receptors play a critical role in...

INTRODUCTION The Behavioral Inhibition System (BIS) and the Behavioral Activation System (BAS) have been theorized as neural systems that regulate approach/withdrawal behaviors. Behavioral activation/inhibition balance may change in neurodegenerative disease based on underlying alterations in systems supporting motivation and approach/withdrawal behaviors, which may in turn be reflected in neur...

Infant cries and facial expressions influence social interactions and elicit caretaking behaviors from adults. Recent neuroimaging studies suggest that neural responses to infant stimuli involve brain regions that process rewards. However, these studies have yet to investigate individual differences in tendencies to engage or withdraw from motivationally relevant stimuli. To investigate this, w...

Abstract Sleep is a vital behavioral and physiological state. It controlled by conserved genes neuronal circuit mechanisms. In the round worm Caenorhabditis elegans , one single neuron called RIS essential for sleep. During sleep, activates to shut down behavior support survival. Here, we summarize how stress leads activation of signaling through immunity longevity pathways becomes crucial surv...