Ca sensitizers may be advantageous for treatment in human heart failure by increasing cardiac force without increasing the Ca transient or energy consumption. To study the mode of action of the Ca sensitizers EMD 57033 (EMD) and CGP 48506 (CGP), their influence on butanedione monoxime (BDM)mediated depression of cross-bridge cycling was analyzed in human myocardium (explanted hearts, dilated ca...

We introduce and empirically evaluate the strategy-affordance hypothesis, which holds that individual differences in strategy use will mediate the relationship between performance on a working memory (WM) span task and another cognitive task only when the same strategies are afforded by both tasks. One-hundred and forty eight participants completed basic memory tasks and verbal span tasks that ...

Signal peptide-CUB-EGF domain-containing protein 3 (SCUBE3) is a member of small family multifunctional cell surface-anchored glycoproteins functioning as co-receptors for variety growth factors. Here we report that bi-allelic inactivating variants in SCUBE3 have pleiotropic consequences on development and cause previously unrecognized syndromic disorder. Eighteen affected individuals from nine...

This study explored the role of attentional and perceptual factors in lexical access by examining the effects of acoustic distortion on semantic priming of spoken words by a sentence context. The acoustic manipulations included low-pass filtering, which was intended to interfere with the sensory encoding of the acoustic signal by reducing intelligibility, and time compression, which was intende...

Three studies are presented that examine why the processing demands within working memory tasks lead to forgetting of the memoranda. In each, separate groups of adult participants were asked to carry out either verbal or nonverbal operations on exactly the same processing materials, while maintaining verbal storage items. The imposition of verbal processing tended to produce greater forgetting,...

Detailed sedimentological study of Devonian black shales from the eastern USA shows that these rocks contain valuable textural clues to their depositional history, clues that hitherto have gone mostly unrecognized. Cryptic bioturbation and subtle erosional features suggest the presence, originally, of much more benthic life and bottom current activity than is commonly assumed for these deposits...

Some individuals are prone to illness, decline, and premature mortality while others recover quickly, maintain health, and live long lives. Personality, an individual’s biopsychosocial pattern of reactions and behaviors, is related to health across time, but the pathways are complex, with interrelated causal and non-causal links. Causal pathways linking personality and health include: health be...

A latent-variable study examined whether verbal and visuo-spatial working-memory (WM) capacity measures reflect a primarily domain-general construct by testing 236 participants in 3 span tests each of verbal WM, visuo-spatial WM, verbal short-term memory (STM), and visuo-spatial STM, as well as in tests of verbal and spatial reasoning and general fluid intelligence (Gf). Confirmatory factor ana...

Conservation efforts to reverse the negative effects of inbreeding in an isolated population of Florida panthers (Puma concolor coryi) resulted in the release of eight Texas females into Florida in 1995 (Seal 1994; Johnson et al. 1998). Since that time, Florida panthers have shown increased productivity, range expansion, and the reversal of a suite of deleterious morphological and physiological...

Conservation planning is only as good as the science on which it relies. This paper evaluates the science underlying the least-cost-path model, developed by Meegan and Maehr (2002) , for the Florida panther, Puma concolor coryi. It also assesses the resulting claim that private lands in central Florida are desirable for panther colonization (Maehr et al. 2002a , p. 187; Maehr 2001 , pp. 3–4; Ma...