Since tumor progression is dependent on the ability of malignant cells to interact with the extracellular matrix, molecules on the cell surface which mediate cell-substratum interactions are likely to be important regulators of tumor invasion and metastasis. The purpose of this study was to examine the distribution of one such group of cell adhesion receptors, the integrins, in benign and malig...

INTRODUCTION A retrospective study of melanocytic naevi was undertaken to assess the degree of clinico-pathological correlation and incidence of histological atypia. MATERIALS AND METHODS The case records from January to March 1996 of all patients with histologically diagnosed melanocytic naevi at the National Skin Centre were analysed. RESULTS Of the 240 lesions removed from 167 patients, ...

Bioptic specimens from 224 melanocytic naevus lesions and 121 seborrheic keratosis lesions were stained with hematoxylin-eosin and examined under the light microscope. Pityrosporum ovale/orbiculare (Malassezia furfur) was found in 35% of melanocytic naevi and in 36% of seborrheic keratoses. The finding of Pityrosporum ovale/orbiculare was confirmed by PAS (periodic acid shift), methenamide silv...

Skin cancer is the most common cancer in the Western world. In order to accurately detect the disease, especially malignant melanoma-the most fatal form of skin cancer-at an early stage when the prognosis is excellent, there is an urgent need to develop noninvasive early detection methods. We believe that polarization speckle patterns, defined as a spatial distribution of depolarization ratio o...

We recently described an in vivo reflectance confocal microscopy (RCM) method and our aim was to evaluate a possible additive value of this type of analysis in the management of melanocytic lesions. In two referral centers (Sydney and Modena), lesions (203 nevi and 123 melanomas (MMs) with a median Breslow thickness of 0.54 mm) were excised on the basis of clinical suspicion (history, dermoscop...

A part of collection of new algorithms for synthesis of melanocytic skin lesion images is briefly described. Presented approach in the developed algorithms based on a semantic conversion of textual description of melanocytic skin lesions into hybrid (vector-raster type) digital respective images of such lesions. It is assumed, that the developed methodology could be successfully used in educati...

Please cite this article as: Collgros H, Lamas-Doménech N. FR-Lentigo maligno, actualización en técnicas diagnósticas y terapéuticas. Actas Dermosifiliogr. 2015;106:135--136. ∗ Corresponding author. E-mail address: [email protected] (H. Collgros). Differential diagnosis includes seborrheic keratosis, solar lentigo, lichenoid keratosis, actinic keratosis, and pigmented actinic keratosis. ...

BACKGROUND The similar genetic background of a pair of twins, and the similar environmental impacts to which they are exposed allow an exact and objective investigation of various constitutional and environmental factors in naevus development. As far as we are aware, this is the first published survey that simultaneously examines cutaneous and ocular pigmented lesions in an appreciable sample o...