INTRODUCTION/OBJECTIVE Benign prostatic hyperplasia is one of the most common diseases in older men. The objective of this study was to evaluate the impact of the surgical treatment of the benign prostatic hyperplasia (BPH) with the methods of open prostatectomy (OP) and transurethral resection of the prostate (TURP) on the quality of life. METHODS The research material was based on 80 patien...

OBJECTIVES The exact cause of benign prostatic hyperplasia (BPH) and prostatic carcinoma is unknown. Changes in the level of the trace element zinc (Zn) are known to be associated with the functioning of different organs (breast, colon, stomach, liver, kidney, prostate, and muscle). This study is aimed at estimating and comparing the zinc levels in the prostate tissue, plasma, and urine obtaine...

The etiology of benign prostatic hyperplasia (BPH) is still obscure. Data supporting an interaction connecting prostate hyperplasia and immune disregulation is accumulating. Serum levels of pro-inflammatory and antiinflammatory cytokines measured by enzyme-linked immunosorbent assay in 3 groups of patients with BPH. The groups included 12 men who had mean prostate specific antigen (PSA) serum c...

Arginase 2, inducible- and endothelial-nitric-oxide synthase (iNOS and eNOS), indoleamine 2,3-dioxygenase (IDO) and TGF-beta, might impair immune functions in prostate cancer (PCA) patients. However, their expression was not comparatively analysed in PCA and benign prostatic hyperplasia (BPH). We evaluated the expression of these genes in PCA and BPH tissues. Seventy-six patients (42 BPH, 34 PC...

Benign prostatic hyperplasia (BPH) is characterized by an enlarged prostate, lower urinary tract symptoms (LUTS), and a decreased urinary flow rate. Common in older men, BPH is a progressive disease that can eventually lead to complications including acute urinary retention (AUR) and the need for BPH-related surgery. Both normal and abnormal prostate growth is driven by the androgen dihydrotest...

Background: Prostatic calculi are common in men who are evaluated for benign prostatic hyperplasia (BPH) or prostate cancer, but the significance of prostatic calculi with respect to urological diseases and symptoms is obscure. In most cases, when symptoms are present, they are usually nonspecific. The majority of calculi are discovered incidentally, usually by means of a radiological investiga...

BACKGROUND This study aims to estimate the prostate-specific antigen density (PSAD) cutoff level for detecting prostate cancer (CAP) in Nigerian men with "grey zone PSA" (4-10 ng/ml) and normal digital rectal examination findings. We addressed this research question: Is the international PSAD cutoff of 0.15 ideal for detecting CAP in our symptomatic patients with "grey zone PSA?" METHODS A...

INTRODUCTION Inflammation is associated with promotion of the initiation of various malignancies, partly due to bacterial infection-induced microenvironmental changes. However, the exact association between microbiota in urine, seminal fluid and the expressed prostatic secretions and benign prostatic hypertrophy and prostate cancer is not clear. MATERIAL AND METHODS In the present study, we i...

Benign prostatic hyperplasia (BPH) is a multifactorial disease, highly associated with aging and characterized by increased prostate smooth muscle (PSM) contractility. Animal models have been employed to explore the aging-associated PSM hypercontractility; however, studies focused in old animals, neglecting initial alterations early ages. The determination of dysfunctions onset crucial understa...