In the title benzimidazole mononuclear complex, [ZnCl(2)(C(13)H(11)N(3))], the Zn(II) ion is four-coordinated in a distorted tetra-hedral geometry by an imidazole N, an amino N and two Cl atoms. The dihedral angle between the benzimidazole and benzene rings is 9.57 (1)°. In the crystal, mol-ecules are linked by weak N-H⋯Cl hydrogen bonds into layers parallel to the bc plane. π-π inter-actions w...

A large group of benzimidazole derivatives are highly effective as an anthelmintics [ 11. Among these, mebendazole (la, methyl 5-benzoylbenzimidazole-2-carbamate) and flubendazole (lb, methyl 5-p-fluorobenzoylbenzimidazole-Z-carbamate) have demonstrated a broad-spectrum of activity against helminth diseases including filarial infections [2-51. In our continuing studies to develop new antifilari...

In the title compound, (C(14)H(13)N(2)O(2))(2)[CuCl(4)]·2CH(4)O, the geometry of the CuC1(4) (2-) ions (Cu site symmetry 2) is inter-mediate between tetra-hedral and square-planar. The dihedral angle between the benzimidazole and benzene ring systems is 8.74(14)°. A network of N-H⋯O, N-H⋯Cl and O-H⋯Cl hydrogen bonds helps to consoldiate the structure. Aromatic π-π stacking inter-actions involvi...

We reported recently the first polymorph of the title compound [Kuai & Cheng (2011a ▶). Acta Cryst., E67, o2787]. A second polymorph of the title compound, C(15)H(12)N(2)O(2), was unexpectedly obtained by the hydro-thermal reaction of the title compound with manganese chloride in the presence of potassium hydroxide at 413 K. The benzimidazole ring system is almost planar, with a maximum deviati...

In the title complex, [Ni(C(9)H(4)N(2)O(4))(C(12)H(8)N(2))(H(2)O)(2)](n), the Ni(II) atom is hexa-coordinated by one N and one O atom from two different 1H-benzimidazole-5,6-dicarboxyl-ate ligands, two N atoms from one 1,10-phenanthroline ligand and two water mol-ecules. The flexible 1H-benzimidazole-5,6-dicarboxyl-ate ligands link the Ni(II) centres, forming an infinite zigzag chain parallel t...

In the title compound, [Mn(C2O4)(C10H7N3S)] n , the Mn(II) cation is chelated by one 2-(1,3-thia-zol-4-yl)-1H-benzimidazole ligand and two oxalate anions in a distorted N2O4 octa-hedral geometry. Two independent oxalate anions are located on individual inversion centers and bridge the Mn(II) cations into a polymeric chain running along [101]. The thia-zole ring is approximately coplanar with th...

In the title mol-ecule, C(19)H(20)N(2)O(4)·H(2)O, the benzimidazole ring system is essentially planar [maximum deviation = 0.013 (11) Å] and is inclined to the 4-meth-oxy-phenyl ring by 30.98 (5)°. In the crystal, O-H⋯O and O-H⋯N hydrogen bonds involving the water mol-ecule link neighbouring mol-ecules, forming a two-dimensional network lying parallel to the bc plane. There are also C-H⋯π and π...

The asymmetric unit of the title compound, C(8)H(5)F(3)N(2), consists of two half-mol-ecules, one lies on a mirror plane and the other is generated by twofold rotation symmetry, with the axis running through the trifluoro-methyl C atom and the attached benzimidazole C atom. The two 2-trifluoro-methyl-1H-benzimidazole mol-ecules are connected by N-H⋯N hydrogen bonds involving the disordered NH H...

The purpose of the present study was to identify the cellular processes and targets affected by treatment with bis-benzimidazole derivatives with chloroalkyl and bromoalkyl moieties (1–4) in the estrogen receptor-negative MDA-MB-231 human breast cancer cells. Treatment of the cells revealed that these compounds inhibited DNA synthesis and irreversibly inhibited the proliferative activity of the...