Benzo[c]cinnolines, thieno[3,2-c]cinnolines, pyrido[3,2-c]cinnolines and the previously undescribed quinoxalino[6,7-c]cinnoline ring system are conveniently prepared by a short synthetic route comprised of Suzuki coupling, base-catalysed cyclisation and deoxygenation. The use of tandem borylation-Suzuki coupling further extends the scope of this process to include highly substituted benzo[c]cin...

In this work, we report the synthesis of three series carbohydrate-based benzo[f]indole-4,9-diones and amino-1,4-naphthoquinone derivatives evaluated their cytotoxic activity against eight human cancer cell lines. Several compounds showed a promising toward tumor lines (half maximal inhibitory concentration (IC50) < 10.0 ?M). The importance substitution pattern quinone on antitumor was also dis...

This study investigated the biodegradation of high-molecular-weight polycyclic aromatic hydrocarbons (PAHs) in liquid media and soil by bacteria (Stenotrophomonas maltophilia VUN 10,010 and bacterial consortium VUN 10,009) and a fungus (Penicillium janthinellum VUO 10, 201) that were isolated from separate creosote- and manufactured-gas plant-contaminated soils. The bacteria could use pyrene as...

A variety of polycyclic aromatic hydrocarbons and their dihydrodiol derivatives, arylamines, heterocyclic amines, and nitroarenes, were incubated with cDNA-based recombinant (Escherichia coli or Trichoplusia ni) systems expressing different forms of human cytochrome P450 (P450 or CYP) and NADPH-P450 reductase using Salmonella typhimurium tester strain NM2009, and the resultant DNA damage caused...

“Pimentón de La Vera” is a smoked paprika regulated by Protected Designation of Origin. The smoking process confers highly-valued sensorial properties to paprika. However, this particular drying also increases the levels polycyclic aromatic hydrocarbons concerning concentrations. In work, two modified dryers were compared traditional dryer as strategy mitigate PAH contamination. Drying paramete...

Abstract The purpose of this study was to evaluate the concentration PAHs and health risk in edible mushrooms using magnetic solid phase extraction (MSPE) gas chromatography/mass spectrometry (GC/MS) method. Based on results, total range from 0.82 6.25 µg/kg (with means 3.85 ± 0.24 µg/kg). In study, acenaphthylene (Ace) had maximum mean level mushroom samples (0.84 0.19 μg/kg) benzo(a)pyrene (B...

Recent studies in mouse tumor systems have indicated a potential therapeutic advantage in combining the radiosensitizer misonidazole (MISO) with cancer chemotherapy drugs. One agent the antitumor activity of which has been enhanced to a greater extent than its hematological or gastrointestinal toxicities is the nitrosourea, 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU). Recently, sensitiz...

BACKGROUND Phenethyl isothiocyanate (PEITC), the most comprehensively studied aromatic isothiocyanate, has been shown to act as an anti-cancer agent mainly through modulation of biotransformation enzymes responsible for metabolizing carcinogens in the human body. Humans are often exposed to carcinogenic factors, some of which through the diet, such as polycyclic aromatic hydrocarbon benzo[a]pyr...

Resveratrol is a natural (poly)phenol primarily found in plants protecting them against pathogens, as well as harmful effects of physical and chemical agents. In higher eukaryotic cells and organisms, this compound displays a remarkable range of biological activities, such as anti-oxidant, anti-inflammatory, anti-cancer, anti-aging, cardio- and neuro-protective properties. Here, biological acti...