PURPOSE To evaluate whether quantity of choroidal tissue directly adjacent to the optic nerve differs between eyes with and without glaucoma and whether beta-zone parapapillary atrophy influences this relationship. DESIGN Prospective cohort study. METHODS Subjects were enrolled in a longitudinal, observational study at our institution. We studied 1 eye of 63 primary open-angle glaucoma (POA...

The determination of the high-resolution three-dimensional solution structure of interleukin 1 beta (IL-1 beta), a protein of 153 residues and 17.4 kDa, which plays a central role in the immune and inflammatory responses, has been determined by heteronuclear (13C and 15N) three- and four-dimensional NMR spectroscopy. The structure is based on 3146 experimental restraints comprising 2780 distanc...

A method is described for the estimation of the true width of fibrillar or rod-like structures from electron micrographs of metal-shadowed preparations. The method is based on variations in the image width as a function of the angle (beta) between the long axis of the fibril and the direction of the shadow in the plane of the preparation. The image width when beta = 0 degrees practically repres...

The refractive index n = 1 - delta + ibeta of Si in the energy range 50-180 eV is investigated with angle-dependent reflectance measurements. The optical constants delta and beta are both determined by fitting to the Fresnel equations. The results of this method are compared with the values in the atomic tables derived from experimental data for beta and implementation of the Kramers-Kronig rel...

BACKGROUND Although it has been demonstrated that the peak height velocity (PHV) is a predictive factor of progression in adolescent idiopathic scoliosis (AIS), little is known about the usefulness of angle progression in clinical practice. The purpose of this study was to establish a relationship between height and angle velocities, as well as to determine if peak angle velocity (PAV) occurs a...

Small proteins like amyloid beta (Aβ) monomers are related to neurodegenerative disorders by aggregation to insoluble fibrils. Small angle neutron scattering (SANS) is a nondestructive method to observe the aggregation process in solution. We show that SANS is able to resolve monomers of small molecular weight like Aβ for aggregation studies. We examine Aβ monomers after prolonged storing in d-...

BACKGROUND Open angle glaucoma (OAG) is an important cause of blindness worldwide. Laser trabeculoplasty, a treatment modality, still does not have a clear position in the treatment sequence. OBJECTIVES The objective of this review was to study the effects of laser trabeculoplasty for OAG. SEARCH STRATEGY We identified trials from CENTRAL in The Cochrane Library, MEDLINE, EMBASE, LILACS and...

Thiol peroxidase, Tpx, has been shown to be a target protein of the salicylidene acylhydrazide class of antivirulence compounds. In this study we present the crystal structures of Tpx from Y. pseudotuberculosis (ypTpx) in the oxidised and reduced states, together with the structure of the C61S mutant. The structures solved are consistent with previously solved atypical 2-Cys thiol peroxidases, ...

in this note, by considering the notions of the intuitionistic general l-fuzzy automaton and $(alpha, beta)$-language, we show that for any $(alpha, beta)$-language $mathcal{l}$, there exists a minimal intuitionistic general l-fuzzy automaton recognizing $mathcal{l}$.we prove that the minimal intuitionistic general l-fuzzy automaton is isomorphic with threshold $(alpha,beta)$ to any $(alpha, be...

AIM To determine utilisation patterns and calculate treatment failure and discontinuation rates in patients with open angle glaucoma treated in the United Kingdom with any of six groups of intraocular pressure (IOP) lowering agents. METHODS The UK General Practice Research Database was used to identify newly diagnosed (after 1 January 1997) open angle glaucoma patients who were naive to thera...