Both carcinogenic and anticarcinogenic properties have been reported for the synthetic antioxidants butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT). The association between dietary intake of BHA and BHT and stomach cancer risk was investigated in the Netherlands Cohort Study (NLCS) that started in 1986 among 120,852 men and women aged 55 to 69 years. A semi-quantitative food f...

UNLABELLED Hyaluronic acid receptor is a glycoprotein of the plasmatic membrane, and the CD44 is its representative, expressed in many cell types where it has the task of cell adhesion. AIM the goal of the present experimental study is to investigate the possibility of using immunohistochemistry to identify the distribution of hyaluronic acid along the vocal fold. MATERIALS AND METHODS We r...

OBJECTIVE Cell adhesion molecules (intracellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1)) and hyaluronic acid, markers of inflammation and fibrosis were monitored in hepatitis C patients to determine whether changes in plasma levels, during antiviral treatment, can predict long-term response to therapy. METHODS In 55 patients with chronic hepatitis C virus (HC...

BACKGROUND To assess the anti-adhesive effect of treatment with hyaluronic acid-carboxymethylcellulose following laparoscopic radical prostatectomy. METHODS This was a randomized, controlled, single-blind, parallel-group study using hyaluronic acid-carboxymethylcellulose in patients who underwent laparoscopic radical prostatectomy. Sixty patients were enrolled in the study. All patients were ...

INTRODUCTION Hearing loss is fairly a common disorder which is usually treated with corticosteroids via systemic administration and/or intra-tympanic injection. This study aimed to compare the effectiveness of intra-tympanic injections of dexamethasone with its combination with hyaluronic acid in patients with sudden sensorineural hearing loss. MATERIALS AND METHODS In this clinical trial, 40...

We developed a new strategy for the functionalization of hyaluronic acid by chemical modification of its C-6 hydroxyl groups through an ether bond to obtain a cysteine-hyaluronic acid conjugate. This conjugate is suitable to prepare injectable and in situ formed hydrogels cross-linked by native chemical ligation and Michael addition under mild conditions.

The appearances and nature of mucin complexes have been studied intensively with synovial fluid and similar concentrations of hyaluronic acid, but there is a paucity of information about mucin complexes precipitated from very dilute hyaluronic acid (for example, 2 to 20 Ktg./ml.), which can probably be attributed to the rarity of natural solutions of this order except in bacterial and cellcultu...

Intra-articular inflammation is associated with a reduction in viscosity of synovial fluid which is due to changes in hyaluronic acid rather than in the protein component of the fluid (Kulonen, 1951; Sundblad, 1953). Hyaluronic acid is a polymer of molecular weight greater than 1 x 106 made up from repeating units of N-acetyl-D-glucosamine and D-glucuronic acid. It is present in concentrations ...

INTRODUCTION Health care professionals are constantly seeking novel approaches to treat pressure ulcers because of the impact they have on patient quality of life and health, as well as the costs associated with treating them. METHODS A review of the literature from 2002-2012 was conducted on the clinical usefulness of hyaluronic acid in tissue regeneration. Reports suggest that the therapeut...