The biliary tract excretion of three cephalosporins, cefazolin, cephaloridine, and cephalothin, was compared in patients with biliary tract disease. In the absence of obstruction, mean antibiotic levels in bile from gall bladder and common duct in patients undergoing cholecystectomy were highest for cefazolin (17 and 31 mug/ml, respectively) than either cephaloridine (7 and 9 mug/ml) or cephalo...

BACKGROUND Livers of infants with biliary atresia and of neonatal mice infected with rotavirus (RRV) have increased expression of interferon-gamma (IFNgamma) and interleukin (IL)-12. While the expression of IFNgamma regulates the obstruction of extrahepatic bile ducts by lymphocytes, the role of IL-12 in the pathogenesis of biliary obstruction is unknown. Based on the role of IL-12 as a key pro...

The management of biliary decompression in malignant hilar carcinoma remains controversial. This review shows the most relevant aspects endoprosthetics for proximal obstruction, including necessity stenting and morphological verification before radical surgery, selection approach to drain etc. main contradictions ways solve them are presented this article, based on evidence researches, internat...

Percutaneous transhepatic biliary drainage (PTBD) is an established procedure for biliary obstruction. However, duodenobiliary or jejunobiliary reflux of the intestinal contents through a PTBD catheter sometimes causes recurrent catheter obstruction or cholangitis. A 64-year-old female patient with a history of choledochojejunostomy was referred to our department with acute cholangitis due to c...

ascaris infestation is still prevalent in the world. in isfahan approximately 77.7 to 90.3 percent of the population is infected. in this communication surgical complications of ascariasis in a series of 29 patients observed in soraya hospital of isfahan during five year period since 1971 are reported. intestinal obstruction was the commonest complication leading to operation (22 cases). the di...

The clearance of etoposide and formation of etoposide glucuronide have been measured in an isolated, perfused rat liver model to evaluate the effect of impaired hepatic function on etoposide kinetics. Hepatocellular injury was produced by pretreatment of rats with allyl alcohol or carbon tetrachloride; ligation of the bile duct simulated obstructive biliary disease. Etoposide clearance (3.59 +/...

BACKGROUND Jaundiced patients undergoing surgical procedures have an increased risk of Gram negative sepsis with potential morbidity and mortality. Depressed Kupffer cell clearance capacity (KCCC) predisposes jaundiced patients to endotoxaemia and its sequelae. Biliary decompression remains the main therapeutic strategy in obstructive jaundice. AIMS This study investigates the efficacy of int...

Biliary changes secondary to portal hypertension have rarely been described in published reports. Twenty consecutive patients with extrahepatic portal venous obstruction, all of whom showed a variable degree of abnormalities in the biliary tract suggestive of sclerosing cholangitis, are described. These biliary abnormalities were: focal narrowing, dilatations, and cholangitic changes affecting ...

Background: Hydatid cyst of the liver may be complicated by spontaneous rupture into the biliary tract with biliary obstruction. Methods: ERCP of hydatid cyst liver with biliary communication was done and bile duct cleared and cyst was assessed for resolution. Results: A 56 year lady who had jaundice, right upper abdomen pain and cholangitis was diagnosed to have hydatid cyst of liver with bili...

Aims To evaluate the success rate and related factors of endoscopic ultrasound guided-biliary drainage (EUS-BD). Material and Methods We conducted a retrospective study among 24 patients with malignant biliary obstruction who underwent EUS-BD after failed ERCP from January 2015 to December 2016 in a tertiary health center. The bilirubin levels before and after the procedure were used to defin...