INTRODUCTION Acute liver failure (ALF) is a multisystem disease with severe impairment of liver function of acute onset. The Paediatric End-stage Liver Disease (PELD) score is used as a predictor of mortality in chronic liver disease, however experience is limited in ALF. OBJECTIVES To evaluate the aetiology and outcomes of children with ALF in a Children's Liver Transplant Centre, and to inv...

BACKGROUND There is a strong correlation between glucose-6-phosphate dehydrogenase (G6PD) deficiency and neonatal hyperbilirubinemia with a rare but potential threat of devastating acute bilirubin encephalopathy. G6PD deficiency was observed in 4-14% of hospitalized icteric neonates in Pakistan. G6PD c.563C > T is the most frequently reported variant in this population. The present study was ai...

OBJECTIVE To evaluate the complement factor 3 levels in children with hepatitis A. METHODS This observational study was conducted at the Infectious Diseases Hospital of Hotan District, China, from September 2014 to January 2015, and comprised children with hepatitis A and controls. The patients were divided into two groups. The ones with total bilirubin less than or equal to 2mg/dl comprised ...

INTRODUCTION Hyperbilirubinemia in a neonate is one of the most common problems that may occur in 60-70 % of term and 80% of preterm babies. It is known to be associated with significant morbidity like neonatal bilirubin encephalopathy and even death. Clinically, and almost exclusively ABO incompatibility occur in 'A' and 'B' blood group babies of O '+ve' mothers. These babies are reported to b...

Neonatal jaundice or hyperbilirubinemia and its evolution to acute bilirubin encephalopathy (ABE) and kernicterus are an important, yet avoidable, origin of newborn deaths, re-hospitalisations and disabilities generally. In this study, a new supervised hybrid bijective soft set neural network-based classification method is introduced for prediction of Egyptian neonatal jaundice dataset. Early p...

A 49 year-old man with a history of alcohol-induced cirrhosis presented for orthotopic liver transplantation. His medical history is remarkable for mild hypertension treated with metoprolol and aldactone; recent admissions for ascitic fluid drainage, spontaneous bacterial peritonitis and transient episodes of hepatic encephalopathy; and a prior history of an open cholecystectomy. His admission ...

Kernicterus is a preventable but devastating neurologic disorder with life long complications. It is caused by severe and inadequately treated hyperbilirubinemia during the newborn period. In the present paper potential causes and risk factors for the occurrence of kernicterus related to the Thai health system that are responsible for the care of newborn infants before and after discharge are d...

OBJECTIVE To describe an unusual case of acute liver failure due to Hodgkin's lymphoma. CASE PRESENTATION AND INTERVENTION A 37-year-old man was admitted with jaundice and abdominal distension. Physical examination showed tender hepatosplenomegaly, ascites, grade I encephalopathy, left cervical (2 x 1 cm) and axillary (1 x 1 cm) lymph nodes. The laboratory data revealed elevated serum bilirub...

conclusions the etiology of exchange transfusion was unidentified in most cases; however, abo incompatibility was the most prevalent cause of hyperbilirubinemia. complications were common after exchange transfusion and should be considered carefully. patients and methods a retrospective study was performed on 28 days old infants who received exchange transfusion due to severe hyperbilirubinemia...

The peroxidase method described in this paper measures non–protein-bound bilirubin by oxidation of the free fraction. The oxidation rate is slow compared with rapid dissociation of albumin-bound bilirubin. Thus, the unbound bilirubin can be estimated from the initial rate of decline in total bilirubin concentration. In the 1970s, severe neonatal hyperbilirubinemia and kernicterus were major cli...