The alkaloid ageladine A, a pyrrole-imidazole alkaloid isolated from marine Agelas sponges shows fluorescence in the blue-green range during excitation with UV light with the highest absorption at 370 nm. The fluorescence of this alkaloid is pH dependent. Highest fluorescence is observed at pH 4, lowest at pH 9 with the largest fluorescence changes between pH 6 and 7. Ageladine A is brominated,...

BACKGROUND In ayurvedic traditional medicine Gentiana kurroo Royle (family; Gentianaceae) is used to treat several metabolic diseases. This plant is rich in various compounds belonging to flavonoids and glycosides. Till now little work has been carried out on immunomodulatory and anti-inflammatory potential of this plant. This study confirms the presence of bioactive compounds and evaluates the...

Alzheimer's disease (AD) is one of the most patient devastating central nervous system diseases with no curative therapy. An effective oral therapy with brain-targeting potential is required that is hampered by blood-brain barrier. Piperine (PIP) is a natural alkaloid with memory enhancing potentials. Oral PIP delivery suffers from its hydrophobicity and first-pass metabolism. In this study, no...

The aim of this work was to improve understanding of the regulation of alkaloid biosynthesis in two Solanaceae plants, Nicotiana tabacum (tobacco) and Hyoscyamus muticus (Egyptian henbane). In order to map the biosynthetic genes involved in the tobacco alkaloid pathway, a functional genomics-based technology was established by combining genome-based transcript profiling (cDNA-AFLP) with targete...

halophilic bacteria grow over a wide range of salt concentrations. in this study we aimed to isolate and screen out the halophilic bacteria and to determine their activity for production of the bioactive compounds. a total of 50 water, sediments and soil samples were collected from maharlu salt lake in southern region of fars-iran and subjected for isolation of the bioactive compound producing ...

A new approach for the stereoselective synthesis of the bicyclic guanidine alkaloid (+)-monanchorin has been developed using a palladium(ii)-catalysed MOM-ether directed Overman rearrangement to establish the second stereogenic centre and a cross metathesis reaction to generate the carbon backbone. In the final stage, a one-pot acid mediated deprotection of aldehyde, guanidine and hydroxyl grou...

Objective: The current study was designed to explore the hepatoprotective activity of Phyllanthus niruri (PN) alkaloid fraction in induced hepatitis in rats. Methods: The rats are divided into 5 groups as per the experimental design. Pre alkaloid treatment of PN was given to the hepatitis rats for 21 d. After completion of the treatment, the serum was collected, and biochemical analysis was car...

Alkaloids represent a highly diverse group of compounds that are related only by the occurrence of a nitrogen atom in a heterocyclic ring. Plants are estimated to produce approximately 12,000 different alkaloids, which can be organized into groups according to their carbon skeletal structures. Alkaloid biosynthesis in plants involves many catalytic steps, catalyzed by enzymes that belong to a w...

Amaryllidaceae occupies a prominent position among the most important alkaloid-rich plant families in globe. Plants of this family show an exceptional ability to produce myriad structurally diverse alkaloids with noteworthy pharmacological and therapeutic potential. Of these alkaloids, narciprimine is rare weakly basic phenanthridone alkaloid that was identified from some species belonging gene...

Supercritical fluid extraction was used to extract the alkaloid N-[7-(3',4'-methylenedioxyphenyl)-2(Z),4(Z)-heptadienoyl]pyrrolidine from leaves of Piper amalago L. A three-level orthogonal array design matrix, OAD OA9(34), was used for optimization of the parameters of supercritical extraction of the alkaloid, employing supercritical carbon dioxide: extraction time (20, 40, and 60 min), temper...