The high degree of specificity that many pathogens have with their plant hosts is well-documented from field observations and genetic analysis. Hundreds of disease-specificity genes have been described in plants (resistance genes) and in pathogens (pathogenicity genes). Significant progress has been made in the genetics of specificity, in Mendelian and, more recently, molecular terms. However, ...

LETTER TO THE EDITOR: Autism is a wide spectrum disorder and a lot of factors play role in the etiology. Autism may accompany some genetic disorders such as fragile X, tuberosclerosis, neurofibromatosis and phenylketonuria [1]. However, the absence of sufficient evidence on the etiological roles of environmental, neuroanatomical and biochemical factors has shifted the direction of research to g...

W. Mark ABBOTT,* Andrew MELLOR,t Yvonne EDWARDS$ and Ten FEIZI*§ *Section of Glycoconjugate Research, M.R.C. Clinical Research Centre, Watford Road, Harrow, Middx. HAl 3UJ, tDivision of Immunology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, and TMRC Human Biochemical Genetics Unit, The Galton Laboratory, University College London, Wolfson House, 4 Stephens...

Recent advances in biochemical and molecular genetics have led to the discovery of new leukoencephalopathies. Despite these advances, many patients with leukoencephalopathy remain undiagnosed. A systematic approach to the investigation of these patients is needed to select the most appropriate testing strategy. In this article, the author presents a clinical and magnetic resonance imaging (MRI)...

Helmholtz Zentrum München, Research Unit Environmental Simulation (E.V., V.V., A.G., J.-P.S.), Institute of Biochemical Plant Pathology (C.L., J.D.), and Research Unit Protein Science (J.M.-P., S.M.H.), D–85764 Neuherberg, Germany; Institute of Plant Physiology and Genetics, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria (V.V.); and Institute for Microbiology, Ernst-Moritz-Arndt University...

Kun Guo, Daniel J. Hassett, and Tingyue Gu National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, People’s Republic of China Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA Department of Chemical and Biomolecular Engineering, Ohio U...

This essay reviews the long tradition of experimental genetics of the Drosophila indirect flight muscles (IFM). It discusses how genetics can operate in tandem with multidisciplinary approaches to provide a description, in molecular terms, of the functional properties of the muscle myofibril. In particular, studies at the interface of genetics and proteomics address protein function at the cell...

The science of medical genetics is progressing rapidly. The practical importance of this pro­gress should be considered by medical doctors. Both genetic and environmental factors are involved in the abnormail phenotypes considered diseases. The relative significance of the two factors varies from disease to disease. All di­seases can be viewed as falling on a spectrum in this regard. Hereditary...

Muriel Wheldale Onslow studied flowers in England with genetic and biochemical techniques in the early twentieth century. Working with geneticist William Bateson [4], Onslow used Mendelian principles and biochemical analysis together to understand the inheritance of flower colors at the beginning of the twentieth century. Onslow's study of snapdragons, or Antirrhinum majus [5], resulted in her ...

Manyof the Reflections articles in this journal have focused on particular biological problems that the authors have devoted their careers to or on particular techniques that have facilitated their biological studies. Although I began my career as a biochemist, one of the most common threads to my research has been the exploitation of a genetic approach, the analysis of suppressor mutations. Pa...