The pharmacokinetics and relative bioavailability/bioequivalence of two formulations of digoxin (CAS 20830-75-5) were assessed in this paper. The study was conducted in 20 healthy Chinese male volunteers according to an open, randomized, single-blind, 2-way crossover study design with a wash-out phase of 14 days. Blood samples for pharmacokinetic profiling were taken up to 72 h post-dose and di...

BACKGROUND Dexlansoprazole is a proton pump inhibitor (PPI) approved for use in dual delayed-release capsule and orally disintegrating tablet (ODT) formulations. AIM To assess effects of food, water, and route of administration on the bioavailability of dexlansoprazole 30-mg ODT. METHODS Two separate open-label, phase 1, single-dose crossover studies were conducted in healthy adults. In stu...

The purpose of this study is to investigate the effect of using replicate design on the intra/inter subject variability and bioequivalence of drugs in healthy volunteers. Model drugs used for analysis were amoxicillin/clavulanic acid combination. 24 healthy subjects participated in this study using 4-phase replicate cross over design. Individual disposition kinetic parameters of areas under pla...

BACKGROUND Rifampicin is a semisynthetic antibiotic derivative of rifamycin used worldwide for the treatment of various forms of tuberculosis. OBJECTIVE The objective of this study was to compare, under fasting conditions in healthy volunteers, the rate and extent of absorption of a generic rifampicin capsule in oral dosage form versus the proprietary equivalent formulation for the purpose of...

Pharmacokinetic data of acamprosate tablets was not accessible on large number human. Rationale to examine the pharmacokinetic properties calcium in healthy male subject, single or multiple dosage administration, evaluate bioequivalence two formulations fast fed environment. This work engross study property Acamprosate dosing under fasting condition.
 Methods: Bioequivalence delayed releas...