Isatin is an endogenous compound identified in humans that possesses a wide range of biological activities. Isatin has anxiogenic, sedative, anticonvulsant activities and acts as a potent antagonist on atrial natriuretic peptide receptors in vitro. A series of p-substituted isatin semicarbazones have shown anticonvulsant activity in MES, scPTZ and scSTY tests. Various isatin-N-Mannich bases of ...

In recent years a large amount of data has been gathered on the biology of thyroid hormone receptors. The receptor proteins have been analyzed from the physiological and structural points of view. Most of the information has been summarized in several recent excellent reviews (1–6). The thyroid hormone receptors (TR) are ligand-modulated transcription factors which are members of a large superf...

Lichens produce a great variety of secondary metabolites and most of them are unique. These chemically diverse lichen substances accumulate on the outer surfaces of the hyphae. They have several biological activities, including photoprotection against intense radiation, as well as allelochemical, antiviral, antitumor, antibacterial, antiherbivore, antioxidant, antipyretic, and analgesic action....

Marine natural products have attracted the attention of biologists and chemists on the world over for the last five decades. The ocean is considered to be a source of potential drugs. Covering around 70% of the planet surface, the oceans possess a huge potential for the new discovery1. The marine environment exhibits an important biodiversity represented by 34 of the 36 phyla of all globe, with...

A facile alcoholysis of 7-methoxymitosanes and 5-methoxyindolequinone under basic conditions was discovered and a series of 7-alkoxymitosanes were synthesized from mitomycins A and B using this reaction. They showed strong antibacterial activity against various Gram-positive and Gram-negative bacteria and were potent inhibitors of cultivating HeLa S-3 cells in vitro. Among them, 7-n-propoxy-7-d...

Proanthocyanidins, also called condensed tannins, are oligomers and polymers of monomeric flavans linked through specific single (B linkages) and double (A linkages) bonds. These secondary plant metabolites have substantial antioxidant activity. They are prevalent in some foods and dietary supplements including several berries, red grapes and their wines, and seeds, baking chocolate, cinnamon, ...

Many compounds bearing five membered heterocyclic rings in their structure have an extensive spectrum of biological activities. The search for new biologically active thiazole analogues continues to be an area of intensive investigation in medicinal chemistry. The present review describes ongoing research in search for new thiazole compounds that can prove useful for the design of future target...

BACKGROUND Mastitis reduces milk yield and alters milk composition. Antibiotics are widely used in the treatment of the disease. However, this widespread use of antibiotics causes both antibiotic residues in milks and antibiotic resistance developed in bacteria. Today's researches are focused on discovering and using new antibiotics against bacteria. OBJECTIVE The aim of this work was to disc...

The various biological activities namely anthelmintic, antiarthropodal, antiviral, antimicrobial, herbicidal, antisarcoptic, acaricidal, insecticidal and miticidal activities exhibited by the hydrazonoyl halides are surveyed. Also, the uses of such halides as pesticides, weed controlling and antihypertensive agents as well as lipoxygenase and cyclooxygenase inhibitors are presented. Furthermore...

Chitosan and its oligosaccharides, which are known to possess multiple functional properties, have attracted considerable interest due to their biological activities and potential applications in the food, pharmaceutical, agricultural and environmental industries. Many researchers have focused on chitosan as a potential source of bioactive materials in the past few decades. This review focuses ...