Optogenetics is a new tool to study neuronal circuits that have been genetically modified to allow stimulation by flashes of light. We study recordings from single neurons within neural circuits under optogenetic stimulation. The data from these experiments present a statistical challenge of modeling a high-frequency point process (neuronal spikes) while the input is another high-frequency poin...

Pairs of Au nanoparticles have recently been proposed as "plasmon rulers" based on the dependence of their light scattering on the interparticle distance. Preliminary work has suggested that plasmon rulers can be used to measure and monitor dynamic distance changes over the 1- to 100-nm length scale in biology. Here, we substantiate that plasmon rulers can be used to measure dynamical biophysic...

Cyanobacteria blooms are a major environmental issue worldwide. Our understanding of the biophysical processes driving cyanobacterial proliferation and the ability to develop predictive models that inform resource managers and policy makers rely upon the accurate characterization of bloom dynamics. Models quantifying relationships between bloom severity and environmental drivers are often calib...

Non-equilibrium driving of biophysical processes is believed to enable their robust functioning despite the presence of thermal fluctuations and other sources of disorder. Such robust functions include sensory adaptation, enhanced enzymatic specificity and maintenance of coherent oscillations. Elucidating the relation between energy consumption and organization remains an important and open que...

OBJECTIVE To evaluate the Bedtime Pass Program (BPP), an extinction-based procedure for treating bedtime resistance in typically developing children. METHODS A randomized, controlled trial in which nineteen 3- to 6-year-old children demonstrating bedtime resistance were randomly assigned to a Bedtime Pass or Monitoring Control group. The experimental condition involved parent monitoring plus ...

The standard life-cycle incomplete-markets model, where households face idiosyncratic income shocks and trade a non-contingent asset, is a workhorse of quantitative macroeconomics. In this paper, we assess the degree of consumption insurance implicit in a plausibly calibrated version of the model, and we compare it to the data. On both actual and simulated data, we apply a technique recently de...

Developing relevant decision-support tools for policymakers to support large-scale implementation of climate-smart agriculture in the Global South is challenging given great diversity biophysical, socio-technical, and organizational conditions. This article describes a pilot exercise inspired by recommendation domain literature that aimed at mapping, beyond “classical” biophysical socio-technic...

The purpose of this study was to analyse how visitors valued a socio-ecological system through the use social media data. We gathered YouTube´s videos Ushuaia city and its surrounding forested landscapes (Tierra del Fuego, Argentina) posted between 2010 2020. used screen time (seconds) each video compare value on biophysical, cultural, biodiversity attributes studied system. Each registered dif...

A lesson utilizing a coarse-grained (CG) Gō-like model has been implemented into the CHARMM INterface and Graphics (CHARMMing) web portal (www.charmming.org) to the Chemistry at HARvard Macromolecular Mechanics (CHARMM) molecular simulation package. While widely used to model various biophysical processes, such as protein folding and aggregation, CG models can also serve as an educational tool ...