The cyclization of b-anilino propionic acids in the presence of polyphosphoric acid (PPA) afforded the 2,3-Dihydroquinoline-4-(1H)-ones in good yields. N,N'-bis(2-carboxyethyl)-4-methyl-1,2-diaminobenzene (7) is cyclized under this condition to produce the 1,5-diaza-2,3,6,7-tetrahydro-4-methyl-pheranthrene-4,8-dione(bis-quinolone) (8).

1,4-bis(triphenyl phosphonium)butane peroxodisulfate(BTPPBPDS) were synthesized by treating 1,4-bis(triphenyl phosphonium)butane dibromide and potassium peroxydisulfate in aqueous solution.This was used mild and efficient reagent for oxidation of alkyl benzenes to their corresponding carbonyl compounds in very good to high yields.

BACKGROUND/AIMS The efficacy of bispectral index (BIS) monitoring during colonoscopic sedation is debated. We aimed to determine whether BIS monitoring was useful for propofol dose titration, and to evaluate differences in sedative administration between expert and inexperienced medical personnel during colonoscopy procedures that required moderate sedation. METHODS Between February 2012 and ...

B-cell lymphoma (BCL)-2-interacting cell death suppressor (BIS) has diverse cellular functions depending on its binding partners. However, little is known about the effects of biochemical modification of BIS on its various activities under oxidative stress conditions. In this study, we showed that H2O2 reduced BIS mobility on SDS-polyacrylamide gels in a time-dependent manner via the activation...

BACKGROUND Cerebral state index (CSI) has recently been introduced as an intra-operative monitor of anaesthetic depth. We compared the performance of the CSI to the bispectral index (BIS) in measuring depth of anaesthesia during target-controlled infusion (TCI) of propofol. METHODS Twenty Chinese patients undergoing general anaesthesia were recruited. CSI and BIS, and predicted effect-site co...

The study was conducted in 60, ASA grade I & II patients for BIS guided sedation during middle ear surgery under local anesthesia. All patients were Pre medicated with Inj. Fentanyl 2μgm/kg and Glycopyrolate 5μg/kg, 10 minutes before surgery. Local anesthesia was given by the experienced ENT surgeon using lidocaine 2% with adrenaline 1:200,000. Patients were randomly divided into two groups. Gr...

PRINCIPLES The aim of this study was to investigate the effect of bispectral index (BIS) monitoring on intra-operative anaesthesia consumption and extubation time. DESIGN Randomised controlled study. METHODS The study included 45 patients undergoing major abdominal surgery under general anaesthesia in a six month period (February - July 2011), aged 18 years or older, and classified as ASA (...