Double-stranded RNA-mediated interference (RNAi), antisense oligonucleotides (ASO), and ribozymes have excellent specificity to their target oncogenic mRNA. They also seem show great promise when it comes treating cancer. The problem is that RNAi, ASO, poor stability are constantly being degraded by nucleases. Researchers made some efforts increase oligonucleotides’ creating phospharimidate Pho...

to analysis the mechanisms of blocking high effects on heavy precipitations in northwest of iran, we selected a short period of heavy precipitation (25-28 october 2008). in this case, weather maps such as mean of sea level pressure, 850-hpa and 500-hpa geopotential height levels were assessed and analyzed for the whole period. the position and movement of the atmospheric systems such as cyclone...

Railroad blocking problem (RBP) is one of the problems that need an important decision in freight railroads. The objective of solving this problem is to minimize the costs of delivering all commodities by deciding which inter-terminal blocks to build and by specifying the assignment of commodities to these blocks, while observing limits on the number and cumulative volume of the blocks assemble...