Coronavirus disease 2019 (COVID-19), the currently prevailing pandemic that has besieged whole world, is caused by a novel coronavirus, named as, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Initially, there was focus on disease, which and most predominant presentation. However, with increasing spread of infection consequent knowledge experience about it become apparent virus w...

Nanomaterials can get into the blood circulation after injection or by release from implants but also by permeation of the epithelium after oral, respiratory or dermal exposure. Once in the blood, they can affect hemostasis, which is usually not intended. This review addresses effects of biological particles and engineered nanomaterials on hemostasis. The role of platelets and coagulation in no...

A major variable in blood coagulation tests is the nature and the amount of surface with which the blood comes in contact. When tests on recalcified plasma are used the methods of preparation and storage of the plasma have also to be considered. The prolonged contact of plasma with a large surface, e.g., with glass powder or asbestos, is accompanied by the loss of many coagulation factors, incl...

The low molecular weight heparin, enoxaparin (by inhibition of factors Xa and IIa) and amide local anaesthetics (by altering platelet function) exert anti-clotting effects. Although these agents are often used in combination during the perioperative period, their potential interactive effect on clotting has not been defined. Blood from 10 ASA I-II patients who received enoxaparin 0.5 mg kg(-1) ...

Patients undergoing cardiac surgery with cardiopulmonary bypass are at risk of increased blood loss and transfusion requirements. Contact of blood with the surgical wound and the artificial surfaces of the extra-corporeal circuit results in a coagulopathy. Haemodilution during cardiopulmonary bypass also aggravates the reduction of haemostatic factors even further. On the other hand, systemic a...

This study investigates the optical properties of human blood during the coagulation process under statics using optical coherence tomography (OCT). OCT signal slope (OCTSS) and 1∕e light penetration depth (d(1∕e)) were obtained from the profiles of reflectance versus depth. Results showed that both OCTSS and d(1∕e) were able to sensitively differentiate various stages of blood properties durin...

Performing a complete blood count (CBC) is a common test performed in neonatal intensive care. Samples reported as "clotted" are not able to be analyzed and require redraw. A perceived "high" clotting rate elicits frustration among team members and has negative effects on patient flow and patient satisfaction. Process mapping and a root cause analysis determined that an educational intervention...

Poly(glycerol-sebacate) (PGS) is an elastomeric biodegradable polyester that could potentially be used to engineer blood vessels in vivo. However, its blood-material interactions are unknown. The objectives of this study were to: (a) fabricate PGS-based biphasic tubular scaffolds and (b) assess the blood compatibility of PGS in vitro in order to get some insight into its potential use in vivo. ...