We examined the effects on whole blood viscosity and coagulation time of various dosages of the synthetic low-molecular protease inhibitors gabexate mesilate and nafamostat mesilate with an oscillation-type viscometer. When either agent was added, blood viscosity decreased dose-dependently along a sigmoid-like curve. Furthermore, coagulation time was shorter with gabexate mesilate than with naf...

T HE EXACT role of the platelet in blood coagulation is the subject of considerable controversy. Although thrombocytopenic plasma exhibits retarded coagulation, a prolonged clotting time is rare in thrombocytopenic purpura. ‘ This has been explained by the theory that even in severe thrombocytopenia sufficient thromboplastin is elaborated to produce normal coagulation.4 In any event, the hemorr...

Introduction: Effects of exercise on different body systems, especially cardiovascular and musculoskeletal systems are evidenced. There is a dynamic homeostatic balance between coagulation and fibrinolysis in normal circulation. Effect of exercise and training on this homeostatic balance has been studied extensively but there are a few studies with regards to analysis of the effects of train...

BACKGROUND AND OBJECTIVE Prediction of postoperative excessive blood loss is useful for management of Intensive Care Unit after cardiac surgery. The aim of present study was to examine the effectiveness of International Society on Thrombosis and Hemostasis scoring system in patients with cardiac surgery. METHOD After obtaining approval from the institutional review board, the medical records ...

BACKGROUND Hypercoagulability in type 2 diabetes mellitus (T2DM) patients increases their risk of cardiovascular diseases. OBJECTIVE The aim of this work was to investigate the hypercoagulation mechanism in T2DM patients in terms of circulating tissue factor (TF). METHODS Whole blood coagulation tests by damped oscillation rheometry and dielectric blood coagulometry (DBCM) were performed. ...

OBJECTIVE Blood flow is considered one of the important parameters that contribute to venous thrombosis. We quantitatively test the relationship between initiation of coagulation and shear rate and suggest a biophysical mechanism to understand this relationship. METHODS AND RESULTS Flowing human blood and plasma were exposed to cylindrical surfaces patterned with patches of tissue factor (TF)...

The aim of this study was to evaluate the effect of mild hypothermia on the coagulation-fibrinolysis system and physiological anticoagulants after cardiopulmonary resuscitation (CPR). A total of 20 male Wuzhishan miniature pigs underwent 8 min of untreated ventricular fibrillation and CPR. Of these, 16 were successfully resuscitated and were randomized into the mild hypothermia group (MH, n = 8...

Perioperative monitoring of blood coagulation is critical to better understand causes of hemorrhage, to guide hemostatic therapies, and to predict the risk of bleeding during the consecutive anesthetic or surgical procedures. Point-of-care (POC) coagulation monitoring devices assessing the viscoelastic properties of whole blood, i.e., thrombelastography, rotation thrombelastometry, and Sonoclot...

Abstract Purpose of Review Coagulopathy is a complex pathological condition manifested through the insufficient or excessive tendency to form blood thrombi, which can be caused by trauma and surgery. A promising strategy mitigate coagulopathy balanced restoration generation thrombin — main enzyme in blood-coagulation system. We review studies focusing on thrombin, traumatic coagulopathy, hemost...