نتایج جستجو برای: blood platelets
تعداد نتایج: 693860 فیلتر نتایج به سال:
At the Research and Production Center of Transfusion platelet production have mainly supported (about 99%) by apheresis. However, apheresis donations have limitations caused by donor fitness due to both their preferences and their platelet pre-count validity. So, it is important to maintain of single donor high-dose plateletpheresis by improving its efficacy and safety. The aim of study was to ...
BACKGROUND Pro-coagulant membrane microvesicles (MV) derived from platelets and leukocytes are shed into the circulation following receptor-mediated activation, cell-cell interaction, and apoptosis. Platelets are sentinel markers of toll-like receptor 4 (TLR4) activation. Experiments were designed to evaluate the time course and mechanism of direct interactions between platelets and leukocytes ...
Flow cytometry was used to determine whether activated platelets and platelet-derived microparticles can be detected directly in whole blood after a hemostatic insult. Two different in vivo models of platelet activation were examined: (1) a standardized bleeding time, and (2) cardiopulmonary bypass. Platelets and microplatelets were identified with a biotinylated anti-glycoprotein (GP)lb antibo...
A GINC OF A BLOOD CELL is associated with the progressive loss of its physiologic functions ultimately leading to disintegration of its structure. Only a few attempts have been made to study aging phenomena in blood platelets. It is known that platelets gradually decrease in size as they age in the circulation.1 Differences in response to osmotic stress have been observed in human platelets.2 T...
BACKGROUND Peripheral blood mononuclear cells (PBMNCs), platelets, and polymorphonuclear leukocytes (PMNs) contain various angiogenic factors and cytokines. METHODS AND RESULTS Unilateral hindlimb ischemia was surgically induced in athymic nude rats, and fluorescence-labeled human blood cells (PBMNCs [10(7) cells]+platelets [10(9)] or PBMNCs [10(7)]+platelets [10(9)]+PMNs [10(7)]) were intram...
e15011 Background: Solid tumors are notorious for their ability to form lethal metastases, sometimes several decades following initial cancer diagnosis. Development of distant metastases is a result the primary tumor shedding cells that travel via lymphatics and blood sites where they can metastases. Platelets known specifically enhance cells’ survival in bloodstream by as yet poorly understood...
The effectiveness of different methods of leukoreduction in preventing alloimmune platelet refractoriness was evaluated in a canine model. Platelets from a random donor dog were administered for up to 8 weeks or until platelet refractoriness. Standard (STD; unmodified) platelets were accepted by 14% of recipients (n 7) compared with 14% for centrifuge leukoreduced (C-LR) platelets (n 21) and 31...
Resolvin E1 is a metabolite of eicosapentaenoic acid (EPA) which one the omega-3 polyunsaturated fatty acids (omega-3 PUFAs). The antiplatelet properties PUFAs are well known, but effect resolvin on platelets via collagen receptors extremely poorly reported. We investigated collagen-induced platelet aggregation, activation, and reactivity, also membrane fluidity. ultimate statistically signific...
Alzheimer's disease (AD) is characterized by neurotoxic amyloid-ß plaque formation in brain parenchyma and cerebral blood vessels known as cerebral amyloid angiopathy (CAA). Besides CAA, AD is strongly related to vascular diseases such as stroke and atherosclerosis. Cerebrovascular dysfunction occurs in AD patients leading to alterations in blood flow that might play an important role in AD pat...
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