Seven infants with persistent neonatal hyperinsulinism were treated in Dhahran Health Centre from 1983 to 1986. The insulin:glucose ratio (serum insulin concentration pmol/l) divided by the blood glucose concentration (mmol/l) ranged from 12 to 636, mean (SD) 177 (201). To control hypoglycaemia, diazoxide (12-24 mg/kg/day) was given in a continuous intravenous glucose infusion (12-22 mg/kg/min)...

Background: Data shows vanadium protects pancreatic beta cells (BC) from diabetic animals. Whether this effect is direct or through the relief of glucose toxicity is not clear. This study evaluated the potential effect of oral vanadyl sulfate (vanadium) on glycemic status and pancreatic BC of normal and diabetic rats. Methods: Rats were divided into five groups of normal and diabetic. Diabetes ...

    Background & Objective:  Acetaminophen is known as the most common agent which causes hepatic and renal toxicity in human and experimental animals at supra-therapeutic doses. The current study investigated the protective effects of Descurainia sophia seed extract on the acetaminophen-induced nephrotoxicity markers in male mice.  Materials & Methods:  Experimental male mice (n=60, Swiss alb...

leukemia is a blood disease which is caused by the inhibition of differentiation and an increased proliferation rate. nature has been known as a rich source of medically useful substances. high diversity of bioactive molecules extracted from marine invertebrates, makes them ideal candidates for cancer researches. the study has been done to investigate cytotoxic effects of dichloromethane brittl...

background: data shows vanadium protects pancreatic beta cells (bc) from diabetic animals. whether this effect is direct or through the relief of glucose toxicity is not clear. this study evaluated the potential effect of oral vanadyl sulfate (vanadium) on glycemic status and pancreatic bc of normal and diabetic rats. methods: rats were divided into five groups of normal and diabetic. diabetes ...

3,4-methylenedioxymethamphetamine (mdma) or ecstasy, has had a widely spread popularity among young adults in recent years. kidney toxicity is one of the consequences of ecstasy. the studies have shown that ecstasy is metabolized by cytochrome p450 to reactive electrophil metabolites which detoxify by glutathione (gsh) conjugation. to our knowledge in vivo study of the effect of glutathione on ...

As a result of growing applications of manufactured nanoparticles, there is an increasing concern aboutpossible side effects of exposure to these materials on human and environment. Nanosilver (n-Ag) has foundwide use in medical applications including development of silver-based dressings and silver-coated medicaldevices. However, toxicity of these particles clue to their dermal use has not bee...

objective: amiodarone as an iodinated benzofuran derivative is a potent antiarrhythmic agent currently used for the treatment of ventricular arrhythmias. pulmonary toxicity is one of the complications of amiodarone therapy. the aim of this study was to determine the toxicity of amiodarone for pneumocytes. materials and methods: 14 male white new zealand rabbits were divided in a control group a...

The relationship between the dose of tacrolimus, trough tacrolimus blood concentration, and selected clinical endpoints (acute rejection, nephrotoxicity, and other toxicities) were examined in a prospective, multicenter clinical trial to validate the use of an enzyme-linked immunosorbent assay (ELISA) for monitoring whole-blood concentrations of tacrolimus in liver transplant patients. A total ...

Introduction: Vincristine (VCR) is potential anti-cancer drug that is highly toxic for renal tissue. This study aimed to evaluate the protective effect of alcoholic extract of saffron stigma against vincristine renal toxicity in male rats. Methods: A total number of 50 rats were randomly divided into 10 groups. Different doses of VCR (0.25, 0.5 and 0.75mg/kg) and saffron (0.5 and ...