We previously reported that in p53 (+ / -) mice that had been given a whole-body dose of 3 Gy at 8 weeks of age, p53-dependent delayed effects of radiation, as manifested in T-cell receptor (TCR) variant fractions (VF) instability in mouse splenocytes, were biphasic, namely, induction of TCR-VF mutation reappeared at 44 weeks. The manifestation of the delayed effects and the measures of biologi...

Introduction: Hesperidin (HES), as the most abundant flavonoid existing in the citrus, is widely used by human daily. The radio-protective effects of Hesperidin have been confirmed in various measurement systems. This study aimed to evaluate the effects of Hesperidin on the changes in the apoptosis level and expression of apoptotic genes target (bax, bcl-2 and ration of bax/bcl-2) in the periph...

INTRODUCTION Heavy ion particle radiation is interesting to know biological effects of space radiation. There are problems to assess the magnitude of radiation-induced damages in the astronauts. It is known that the bone minerals reduce after flight, the cause might be estimated by mainly microgravity. However, there are few studies on effects of heavy ion particle irradiation to bone metabolis...

fed a diet consisting of natural foodstuffs than when main tained on a semipurified ration. Whereas these comparative differences between stock rations and purified diets relative to tumor incidence have been evaluated in terms of carcinogenic compounds and spontaneously appearing tumors, to our knowledge this effect has never been assessed in regards to exposure to sublethal doses of total-bod...

PURPOSE To evaluate changes in vertebral marrow signal intensity that occur over time in children undergoing craniospinal radiation therapy, specifically evaluating for the occurrence and timing of marrow regeneration. METHODS MR images of nine pediatric patients (ages 4 to 12 years) with posterior fossa medulloblastoma who received total spinal irradiation (24 to 40 Gy) and had at least thre...

The prodromal syndrome of radiation sickness is characterized by nausea and vomiting but the pathophysiology and the treatment of this entity is largely unknown. We investigated this problem by determining the effects of ionizing radiation on gastric function with and without administration of the dopamine antagonist domperidone. We measured gastric electrical control activity (waves per minute...

SUMMARY We have studied the transplantability and growth in syngeneic hosts of a malignant alveolar cell carcinoma of the BALB/c mouse lung. In untreated mice, the cancer can be established with fewer than 100 cells and grows with a volume doubling time of 3. 1 days. Total-body irradiation of the host with 500 R 2 hr prior to s.c. inoculation with tumor cells does not affect the transplantabili...

A randomized trial was performed to compare two regimens of total body irradiation in patients with chronic myeloid leukemia treated by allogeneic marrow transplantation while in the chronic phase. All patients received cyclophosphamide 120 mg/kg followed by total body irradiation and marrow from HLA-identical siblings. Cyclosporine and methotrexate were used for prophylaxis against acute graft...

The objective was to study the effects of one time exposure to small clinically relevant dose of 60 cobaltgamma ( 60 Co-γ) radiation on histological changes in brain and consequent effects on conditioned taste aversion (CTA) in experimental rats. Rats were total body 60 Co-γ-irradiated in GammaCell; CTA to saccharin was assessed in terms of saccharin preference ratio (SPR) using a standardized ...