Like humans with sleep apnea, rats exposed to chronic intermittent hypoxia (CIH) experience arterial hypoxemias and develop hypertension characterized by exaggerated sympathetic nerve activity (SNA). To gain insights into the poorly understood mechanisms that initiate sleep apnea/CIH-associated hypertension, experiments were performed in rats exposed to CIH for only 7 days. Compared with sham-t...

BACKGROUND The safety of testosterone supplements in men remains unclear. In the present study, we tested the hypothesis that in young and old male spontaneously hypertensive rats (SHR), long-term testosterone supplements increase blood pressure and that the mechanism is mediated in part by activation of the renin-angiotensin system. METHODS AND RESULTS In untreated males, serum testosterone ...

Commissural nucleus of the solitary tract (commNTS) lesions transitorily (first 5 days) reduce mean arterial pressure (MAP) in spontaneously hypertensive rats (SHR), and lesions of the tissue surrounding the anteroventral third ventricle (AV3V region) chronically reduce MAP in other models of hypertension. In the present study, we investigated the effects of combined AV3V+commNTS electrolytic l...

Literature review papers are highly influential in directing academic discourse, not only because they map the state of art a subject area, but also show future research prospects by identifying weaknesses, limitations, and gaps extant body knowledge on particular [...]

We have analyzed the sma-5(n678) mutant in C. elegans to elucidate mechanisms controlling body size. The sma-5 mutant is very small, grows slowly and its intestinal granules look abnormal. We found a 15 kb deletion in the mutant that includes a 226 bp deletion of the 3' end of the W06B3.2-coding sequence. Based on this result, rescue experiments, RNAi experiments and a newly isolated deletion m...

In a QTL mapping study with an F2 population of mice, we have shown that one or more sex-linked factors account for a large part of the divergence between mouse lines selected for high and low body weight. Here, we describe a study undertaken to map the putative X-linked quantitative trait loci (QTLs) by backcrossing segments of chromosome from the high line onto an inbred line derived from the...

The Valsalva maneuver can be used as a noninvasive index of autonomic control of blood pressure and heart rate. The purpose of this investigation was to test the hypothesis that sympathetic mediated vasoconstriction, as referenced by hemodynamic responses during late phase II (phase IIb) of the Valsalva maneuver, is inhibited during whole body heating. Seven individuals (5 men, 2 women) perform...

In 2015 ICD-10-PCS replaced ICD-9-CM for coding medical procedures in the U.S. We explored two methods to automatically map SNOMED CT surgical procedures to ICD-10-PCS. First, we used MetaMap to lexically map ICD-10-PCS index terms to SNOMED CT. Second, we made use of the axial structure of ICD-10-PCS and aligned them to defining attributes in SNOMED CT. Lexical mapping produced 45% of correct ...

In order to track and recognize the movements of multiple people using multiple cameras, each person needs to be segmented and identified in the image of each camera. We propose a method that tracks multiple people and identifies their body parts in multiple camera images. Estimation of the human positions and identification among the multiple cameras is mainly based on the silhouettes method c...