Bone exhibits a great ability for endogenous self-healing. Nevertheless, impaired bone regeneration and healing is on the rise due to population aging, increasing incidence of bone trauma and the clinical need for the development of alternative options to autologous bone grafts. Current strategies, including several biomolecules, cellular therapies, biomaterials, and different permutations of t...

Healing of bone defects is the most frequent cause of failure in surgical treatments of an odontogenic ostitic processes. The aim of this study was to determine successfulness in healing of bone defects after implantation of alloplastic co-polymer-polyglycol bone implant. A group of 45 cases with periradicular ostitic processes were examined. The densitometric measurements were taken from radio...

BACKGROUND Large segmental defects in bone do not heal well and present clinical challenges. This study investigated modulation of the mechanical environment as a means of improving bone healing in the presence of bone morphogenetic protein (BMP)-2. Although the influence of mechanical forces on the healing of fractures is well established, no previous studies, to our knowledge, have described ...

Introduction: Structural bone allografts are frequently used to reconstruct bone defects in the extremities as well as for spinal fusion surgery. Failed healing at the graft-host junction is one of the most frequent complications of allograft surgery. However, the factors that regulate healing and graft incorporation remain poorly understood. The goal of these studies is to examine the molecula...

OBJECTIVES To review the systemic impact of smoking on bone healing as evidenced within the orthopaedic literature. METHODS A protocol was established and studies were sourced from five electronic databases. Screening, data abstraction and quality assessment was conducted by two review authors. Prospective and retrospective clinical studies were included. The primary outcome measures were bas...

There are growing demands for bioactive titanium implants that could shorten the healing period, promote faster rehabilitation, and thereby increase the success rate of treating patients with poor bone quality. A synthetic receptor-binding peptide mimicking bone morphogenetic protein-2 (BMP-2) was covalently linked to a titanium alloy with two types of topography--machined (TiMA) and rough (TiG...

BACKGROUND Calcium phosphate (CaP)-hybridization of tendon grafts has been shown to improve tendon-to-bone healing. The purpose of this study was to clarify the influence of different tendon graft placement methods on tendon-to-bone healing using CaP-hybridized tendon grafts in anterior cruciate ligament (ACL) reconstructions in rabbits. METHODS We compared two methods of tendon graft placeme...

There is a compelling clinical need for bone grafts with initial bone-like mechanical properties that actively remodel for repair of weight-bearing bone defects, such as fractures of the tibial plateau and vertebrae. However, there is a paucity of studies investigating remodeling of weight-bearing bone grafts in preclinical models, and consequently there is limited understanding of the mechanis...

background and aims. recent literature shows that accelerated portland cement (apc) is a non-toxic material that may have potential to promote bone healing. the objective of this study was to histologically evaluate periodontal healing focusing on new bone regeneration following implantation of apc into intra-bony defects in dogs. materials and methods. three-wall intra-bony periodontal defects...

OBJECTIVE This study aims to experimentally investigate the efficiency of Ankaferd Blood Stopper (ABS) on early and long-term bone healing and its effects on bone surfaces. MATERIALS AND METHODS Thirty adult male Wistar albino rats were used in the study. These rats were randomly divided into three groups, and bilaterally bone defects were created in the femur of each rat. A 3.0-mm-deep monoc...