+*Jayabalan P; *Waters NP, *Cook CR; *Kuroki K; *Carson W; *Cook JL +*Comparative Orthopaedic Laboratory, University of Missouri, Columbia, MO [email protected] Introduction: Repair of chronic tears of the rotator cuff fail in 30-90% of cases. Current repair techniques do not re-establish normal bone-tendon (B-T) or tendon-muscle (T-M) junctions. Optimizing the strength and function at these ...

OBJECTIVE Delivery of chitosan to subchondral bone is a novel approach for augmented marrow stimulation. We evaluated the effect of 3 presolidified chitosan-blood implant formulations on osteochondral repair progression compared with untreated defects. DESIGN In N = 5 adult sheep, six 2-mm diameter Jamshidi biopsy holes were created bilaterally in the medial femoral condyle and treated with p...

OBJECTIVE Contrast-enhanced computed tomography (CECT) has been introduced for the evaluation of cartilage integrity. Furthermore, CECT enables imaging of the structure and density of subchondral bone. In this laboratory study, we investigate the potential of microCECT to simultaneously image cartilage and subchondral bone for the evaluation of tissue healing. DESIGN Osteochondral lesions (Ø ...

Foraminifera carbonate exoskeleton was hydrothermally converted to biocompatible and biodegradable zinc-tricalcium phosphate (Zn-TCP) as an alternative biomimetic material for bone fracture repair. Zn-TCP samples implanted in a rat tibial defect model for eight weeks were compared with unfilled defect and beta-tricalcium phosphate showing accelerated bone regeneration compared with the control ...

The reconstitution of lost bone is a subject that is germane to many orthopedic conditions including fractures and non-unions, infection, inflammatory arthritis, osteoporosis, osteonecrosis, metabolic bone disease, tumors, and periprosthetic particle-associated osteolysis. In this regard, the processes of acute and chronic inflammation play an integral role. Acute inflammation is initiated by e...

Introduction It has been well documented that bone marrow stromal cells (MSCs) are progenitors of various structural and connective tissues, including bone, cartilage, and fat. Recent studies reported that MSCs could suppress lymphocyte proliferation in vitro and allogeneic MSCs implanted by systemic infusion could “home” to bone marrow of nonMHC matched baboons. These results have positive imp...