Multiple myeloma is a plasma cell cancer that leads to a dysregulated bone remodeling process. We present a partial differential equation model describing the dynamics of bone remodeling with the presence of myeloma tumor cells. The model explicitly takes into account the roles of osteoclasts, osteoblasts, precursor cells, stromal cells, osteocytes, and tumor cells. Previous models based on ord...

The effectiveness of treatment for children with B-cell non-Hodgkin lymphomas (B-NHL) has reached 85–90% after the introduction modern risk-adapted regimens that involve risk group stratification based on tumor stage. Bone marrow involvement is traditionally evaluated using quantitative morphological analysis cells which has, however, a lower sensitivity compared to molecular genetic methods. I...

An ameloblastic fibroma (AF) is a proliferative mixed tumor which includes components of both odontogenic epithelium and mesenchymal tissue. It relatively rare neoplasm, accounting for approximately only 1.5－4.5% tumors. This case report describes an AF that occurred in the mandibular anterior tooth region 9-year-old girl who presented with chief complaint swelling left region. Intraoral examin...

BACKGROUND Approximately half of the patients diagnosed with localized esophageal cancer die of metastatic disease within the first 2 years following tumor resection. The development of monoclonal antibodies (MAbs) directed against epithelial cell-associated and tumor antigens has enabled the detection of single disseminated tumor cells in secondary organs. PURPOSE We used MAbs directed again...

background: bacterial dna has immunostimulatory effects on different types of immune cells such as dendritic cells (dcs). application of dcs as a cellular adjuvant represents a promising approach in the immunotherapy of infectious disease and cancers. objectives: to investigate the effect of tumor antigen pulsed dcs in the presence of cpg-1826 in treatment of a murine model of cancer. methods: ...

primitive neuroectodermal tumor (penets) is an uncommon malignancy of bone and soft tissue witch rarely occurs in the kidney. in more than 90% of the cases, the tumor cells relieves a balanced translocation (11; 22) (q24; q12). immunohistochemical staining may be required for diagnosis of penet. the cells of tumor express cd99, vimentin, nse, fl1 but do not express ck, lca, myogenin, and wt1. w...

Of the estimated 565,650 people in the U.S. who will die of cancer in 2008, almost all will have metastasis. Breast, prostate, kidney, thyroid and lung cancers metastasize to the bone. Tumor cells reside within the bone using integrin type cell adhesion receptors and elicit incapacitating bone pain and fractures. In particular, metastatic human prostate tumors express and cleave the integrin A6...

Bone is one of the most common sites of metastasis in solid malignancy. Contributing to this osteotropism are the dynamic interactions between tumor cells and the numerous cell types resident in the normal bone, particularly osteoclasts and osteoblasts, which create a tumor supporting microenvironment. However, disseminated cells are detected in the bone marrow long before evidence of metastati...

Parathyroid carcinoma is a rare cause of primary hyperparathyroidism and occurs in one percent of cases. Most of the patients at the time of diagnosis are young and the mean age is 40 year-old and occur with equal frequency in both sexes. In most series, serum calcium levels are ≽ 14 mg/dl and in half of them, a palpable cervical mass is evident. Clinical manifestations are maily due to hyperca...

Objective: To test the hypothesis that zoledronic acid will inhibit tumor-induced osteolysis and reduce tumor growth and invasion in a xenograft mouse model of bone invasive oral squamous cell carcinoma (OSCC). In humans, OSCC is the 6th most common cancer in the world. Bone invasion frequently occurs and is associated with poor prognosis and reduced survival. OSCC is the most commonly diagnose...