Wrist-worn wearable devices equipped with heart activity sensors can provide valuable data that be used for preventative health. However, hearth analysis from these suffers noise introduced by motion artifacts. Methods traditionally to remove outliers based on yield discarding clean data, if some movement was present, and accepting noisy i.e., subject still but the sensor misplaced. This work s...

Individuals in the Global North wishing to support people South can purchase a fundraising bracelet order ‘change lives’. This article examines use of bracelets for International Development (FBID) as form ‘New Responsibility’. We illustrate through database and critical discourse analysis that FBID campaigns are distinctly feminized version ID aid where women engaged consumers, campaign founde...

This study provides a new method for quantifying the cyclotide kalata B1 in both plasma and brain homogenate. Cyclotides are ultra-stable peptides with three disulfide bonds that are interesting from a drug development perspective as they can be used as scaffolds. In this study we describe a new validated LC-MS/MS method with high sensitivity and specificity for kalata B1. The limit of quantifi...

The cyclotides are a large family of circular mini-proteins containing a cystine knot motif. They are expressed in plants as defense-related proteins, with insecticidal activity. Here we investigate their role in membrane interaction and disruption. Kalata B1, a prototypic cyclotide, was found to induce leakage of the self-quenching fluorophore, carboxyfluorescein, from phospholipid vesicles. A...

Cell penetrating peptides have been regarded as promising vectors to deliver hydrophilic molecules inside cells. Although they are great tools for research and have high potential as drug delivery systems, their application as drugs is impaired by their low stability in serum. Cyclotides, cyclic disulfide-rich peptides from plants, are ultra-stable molecules that have inspired applications in d...