objective(s):estrogen (e2) has neuroprotective effects on blood-brain-barrier (bbb) after traumatic brain injury (tbi). in order to investigate the roles of estrogen receptors (ers) in these effects, er-α antagonist (mpp) and, er-β antagonist (phtpp), or non-selective estrogen receptors antagonist (ici 182780) were administered. materials and methods: ovariectomized rats were divided into 10 gr...

Hexylene glycol buffered at pH 6 .4 (7) will preserve microtubules from mammalian brain in homogenates (9) . The observations presented here show that hexylene glycol is better than ethanol or sucrose for preserving the microtubules ; nevertheless, the concentration of microtubules decreases with time even in the presence of hexylene glycol . Cold, autolysis, divalent cations, and mitotic spind...

The aim of this study was to determine the effect of prolonged intensive cycling and postexercise recovery in the heat on brain sources of altered brain oscillations. After a max test and familiarization trial, nine trained male subjects (23 ± 3 yr; maximal oxygen uptake = 62.1 ± 5.3 ml·min(-1)·kg(-1)) performed three experimental trials in the heat (30°C; relative humidity 43.7 ± 5.6%). Each t...

Traumatic brain injury is characterized by initial tissue damage, which then can lead to secondary processes such as cell death and blood-brain-barrier disruption. Clinical and preclinical studies of traumatic brain injury typically employ anatomical imaging techniques and there is a need for new molecular imaging methods that provide complementary biochemical information. Here, we assess the a...

BACKGROUND The neuroprotective effects of cooling the spinal cord in a sheep model by a self-contained intrathecal catheter was reported recently by the authors. The present study was designed to determine if cooling catheters in the lateral ventricles of the brain can effectively cool the CSF and thereby reduce brain temperature while maintaining systemic normothermia. METHODS The cooling ca...

introduction: 99mtc-mibi has been proposed for use as an imaging agent for various tumors, including breast cancer, lung cancer, lymphomas, melanomas and brain neoplastic lesions. brain tumors are very common and radiotherapy being major part of treatment following surgery. after radiotherapy, deteriorating clinical status can be due to either radiation necrosis or recurrent tumor. computed tom...

background: the goal of this study was to determine the reliability of tcd in evaluation of vertebrobasilar arteries in comparison with brain mra in patients suffering from acute vertebrobasilar stroke. methods: samples were patients with definite clinical diagnosis of vertebrobasilar stroke. for all patients brain mri, mra and tcd were performed during the first 48 hours of admission. basilar ...