BACKGROUND After kidney transplantation, decreased graft survival is seen in grafts from brain dead (BD) donors compared with living donors. This might result partly from a progressive nonspecific inflammation in the graft. In this study, we focused on the effects of BD on inflammatory response (adhesion molecules, leukocyte invasion, gene expression) and stress-related heat shock proteins in t...

BACKGROUND Kidneys derived from brain-dead donors have inferior outcomes after transplantation compared to kidneys from living donors. Strikingly, early and profound serum levels of IL-6 in brain-dead donors are observed. IL-6 is the main regulator of the acute phase response (APR). The aim of this translational study was to investigate the expression of renal acute phase proteins (APPs) follow...

PurposeThe increased use of donors after circulatory death (DCD) has expanded the breath organ donation across many heart transplant centers. However, there are concerns about stability and quality compared to traditional brain (DBD) organs. The objective our study is analyze differences between DCD DBD.MethodsSingle center, retrospective data from procured inception program at institution. We ...

INTRODUCTION To date, a specific marker to evaluate and predict the clinical course or complication of the liver-transplanted patient is not available in clinical practice. Increased procalcitonin (PCT) levels have been found in infectious inflammation; poor organ perfusion and high PCT levels in the cardiac donor appeared to predict early graft failure. We evaluated PCT as a predictor of early...

Background and aims: There are different causes for brain death including head trauma, cerebrovascular accidents and intracranial space-occupying lesions. The present study was aimed to determine the causes of brain death in Chahar Mahal and Bakhtiari province due to high turnover of trauma in this area during 2003 to 2013...

Background: This cross-sectional study was conducted to compare the cost-effectiveness of three therapeutic methods of long-term hemodialysis, kidney transplant from a living person and kidney transplant from a cadaver utilizing Disability Adjusted Life Years (DALY) using data from the records of patients referred to Afzalipour Hospital of Kerman in 2012.   Methods: This cross-sectional...

CASE-REPORT A 45 year old male working as a labourer in the agricultural sector was brought to the emergency room with complaints of difficulty in opening the eye-lids, dysphagia, dysphonia, dyspnea, and progressive weakness in all four limbs, after awakening from sleep. At presentation, patient had no spontaneous respiratory efforts and was deeply cyanosed. Endotracheal intubation was performe...

BACKGROUND The reconstruction of the posterior trunk, especially with large dead spaces, remains challenging. Regional muscle flaps may lack adequate volume and reach. The purpose of this report was to evaluate the efficacy of deepithelialized free-style perforator-based propeller flaps to obliterate defects with large dead space. METHODS A total of 7 patients with defects on the posterior tr...

To the Editor: In a recent issue of Critical Care Medicine, with interest we read the article by Dhanani et al (1), concerning vital signs after circulatory arrest following withdrawal of lifesustaining therapy. The article has timely given the persistent controversy regarding criteria of death in circulatory death organ donors. How many minutes after circulatory arrest can we consider the pati...