Cyclin D1 plays an important role in the development of breast cancer and is required for normal breast cell proliferation and differentiation associated with pregnancy. We show that ectopic expression of cyclin D1 can stimulate the transcriptional activity of the estrogen receptor in the absence of estradiol and that this activity can be inhibited by 4-hydroxytamoxifen and ICI 182,780. Cyclin ...

Primary breast lymphoma (PBL) is a clinicopathological entity characterized by the appearance of a unilateral breast mass of months of evolution, infrequently accompanied by signs of skin edema, retraction, erythema and nipple involvement. This rare situation is especially observed during pregnancy or postpartum, suggesting that tumor growth is influenced by hormonal stimulation, although its a...

Lycopene, the major carotenoid found in tomatoes, is a potent antioxidant associated with the prevention of degenerative diseases such as breast cancer. This effect could be due to the interaction between lycopene and retinoic acid receptors as well as the stimulation of gap junction communication and synthesis of connexin 43. The expression of the RARalpha, RARbeta, and Cx43 proteins was analy...

Tissue inhibitors of matrix metalloproteinase (TIMPs) are multifunctional proteins with both matrix metalloproteinase (MMP) inhibitory effects and growth-regulatory activity. TIMPs inhibit MMP activity, suggesting a use for cancer gene therapy. However, here we report that systemic administration of human TIMP-4 by electroporation-mediated i.m. injection of naked TIMP-4 DNA stimulates tumorigen...

Primary breast lymphoma (PBL) is a clinicopathological entity characterized by the appearance of a unilateral breast mass of months of evolution, infrequently accompanied by signs of skin edema, retraction, erythema and nipple involvement. This rare situation is especially observed during pregnancy or postpartum, suggesting that tumor growth is influenced by hormonal stimulation, although its a...

Primary breast lymphoma (PBL) is a clinicopathological entity characterized by the appearance of a unilateral breast mass of months of evolution, infrequently accompanied by signs of skin edema, retraction, erythema and nipple involvement. This rare situation is especially observed during pregnancy or postpartum, suggesting that tumor growth is influenced by hormonal stimulation, although its a...

The innate immune response, which depends on so-called pattern-recognition receptors (PRRs) is an evolutionarily old immune response able to elicit a defensive response against a vast array of pathogens. The purpose of this review is to revisit the role of innate immunity in breast carcinoma from the oldest therapeutic approach using bacillus Calmette-Guerin to the recent findings on the manipu...

Primary breast lymphoma (PBL) is a clinicopathological entity characterized by the appearance of a unilateral breast mass of months of evolution, infrequently accompanied by signs of skin edema, retraction, erythema and nipple involvement. This rare situation is especially observed during pregnancy or postpartum, suggesting that tumor growth is influenced by hormonal stimulation, although its a...

Primary breast lymphoma (PBL) is a clinicopathological entity characterized by the appearance of a unilateral breast mass of months of evolution, infrequently accompanied by signs of skin edema, retraction, erythema and nipple involvement. This rare situation is especially observed during pregnancy or postpartum, suggesting that tumor growth is influenced by hormonal stimulation, although its a...

Primary breast lymphoma (PBL) is a clinicopathological entity characterized by the appearance of a unilateral breast mass of months of evolution, infrequently accompanied by signs of skin edema, retraction, erythema and nipple involvement. This rare situation is especially observed during pregnancy or postpartum, suggesting that tumor growth is influenced by hormonal stimulation, although its a...