background: asthma is a chronic inflammatory disorder of the airways. the available treatment options have major limitations owing to low efficacy, associated adverse events and compliance issues. therefore, the health burden of bronchial asthma is increasing globally at an alarming rate, providing a strong impetus for the development of new therapeutics. myrica sapida is known traditionally in...

allergic rhinitis and asthma share common  epidemiological features and inflammatory processes. the aim of the present study was to document the influence of natural allergen exposure in exhaled no  (eno)  and in spirometric parameters of patients with seasonal allergic rhinitis(sar) and to investigate the differences among subjects with positive versus negative bronchial provocation to metacho...

churg strauss syndrome (css) is a form of primary vasculitis that is characterized by severe eosinophilia and often granulomatous inflammation as well as history of asthma or allergy. previously, the association between cysteinyl leukotrien receptor antagonists (ltras), corticosteroid withdrawal or a sudden change in its used method and css had been established. we report three cases that have ...

I dentification of new diseases or a cluster (syndrome) of disorders with very similar pathological, radiological and clinical aspects, even sharing common pathogenic steps, is an important fact to build up the scientific soul of the complex and intriguing art called medicine. In this issue of the European Respiratory Journal, a new distinct syndrome, hypereosinophilic obliterative bronchioliti...

The two main sources of blood supply to the lungs and their supporting structures are the pulmonary and bronchial arteries. The bronchial arteries account for 1% of the cardiac output but can be recruited to provide additional systemic circulation to the lungs in various acquired and congenital thoracic disorders. An understanding of bronchial artery anatomy and function is important in the ide...

We have measured the competitive antagonistic effect of chlorpheniramine in bronchi of 8 normal and 12 asthmatic subjects. Classical pharmacological theory states that the degree of competitive antagonism depends only upon 1) antagonist concentration at the receptor, and 2) receptor affinity. Delivery and affinity also influence agonist responsiveness, but measurement of bronchial antagoni...

important structures for conditioning luminal gas temperature and humidity. Functionally, nasal vasculature resemble bronchial vasculature in their response to environmental, physical, chemical, nervous and humoral stimuli. M i have extensively studied several factors which regulate nasal airflow resistance(Rnaw)and nasal blood flow(Qn)in man, including nasal or oral hyperventilation and physic...

RATIONALE AND OBJECTIVES The authors performed this study to determine if bronchial wall thickening is present in children with moderate to severe asthma during periods free from clinical bronchoconstriction. MATERIALS AND METHODS The authors obtained low (radiation) dose thin-section computed tomographic (CT) scans in each of 18 control subjects and 21 children with moderately severe but sta...

Anomalies of the bronchus can be both congenital and acquired. Several different congenital aberrations of the bronchial anatomy are commonly encountered including tracheal bronchus, accessory cardiac bronchus, and bronchial agenesis/aplasia/hypoplasia. In addition, Williams-Campbell syndrome and cystic fibrosis are two other congenital conditions that result in bronchial pathology. Acquired pa...