Background & Aims: This study was carried out to determine the leading indications for corneal transplantation in Kerman province. Methods: Medical records of 186 patients underwent corneal transplantation during 3 years (2004-2006) in Shafa Medical Center were evaluated retrospectively. The initial diagnosis and causes of corneal grafting were recorded. Infectious keratitis (Bacterial, Fungal,...

OBJECTIVES To evaluate treatment with methotrexate in patients with bullous pemphigoid and to elucidate the reduced adverse effects compared with standard treatment with prednisone. DESIGN Retrospective study (January 1, 1999-December 31, 2003). SETTING The Department of Dermatology and Venerology, Karolinska University Hospital. PATIENTS A total of 138 consecutive patients with bullous p...

Graft-vs-host disease is still the leading cause of morbidity and mortality in patients undergoing bone marrow transplantation. It is important to start treatment early to reduce the severity and consequences of this complication. Cutaneous lesions are often the presenting compliant of graft-vs-host disease and presage visceral involvement. We present the case of a 45-year-old woman with multip...

Chronic bullous disease of childhood (CBDC) is an autoimmune blistering disease that is characterized by Immunoglobulin A (IgA) deposits at the basement membrane zone. IgA autoantibodies (aAbs) from the serum of patients with CBDC react with antigens of 97 kDa (LABD97) and 120 kDa (LAD-1), and both of which are fragments of the extracellular domain of bullous pemphigoid 180 (BP180, type XVII co...

© 2010 The Authors. doi: 10.2340/00015555-0871 Journal Compilation © 2010 Acta Dermato-Venereologica. ISSN 0001-5555 Bullous amyloidosis is a rare cutaneous manifestation of systemic AL amyloidosis that may be associated with multiple myeloma or occult plasma cell dyscrasia (1–3); only approximately 30 cases have been reported until now (4, 5), although its incidence may be higher than is gener...

AIM OF STUDY To study the efficacy of tetracycline (or doxycycline) and nicotinamide in the treatment of less extensive bullous pemphigoid. METHODS An open trial of 11 patients with bullous pemphigoid. Treatment was initiated with tetracycline 1.5-2 g/day and nicotinamide 1.5-2 g/day and gradually tapered down. Doxycycline was substituted for tetracycline in patients who could not tolerate te...

An outbreak of staphylococcal bullous impetigo occurred over a period of five months in a maternity ward involving seven infected and two colonised neonates. The skin lesions were due to epidermolytic toxin A-producing Staphylococcus aureus. Infection control measures were implemented and a retrospective case-control study performed. Contact with an auxiliary nurse was the only risk factor for ...

Background: Infantile vesiculobullous lesions are caused by infections, drugs, congenital and autoimmune disorders. Mastocytosis refers to over-proliferation and accumulation of tissue mast cells, encompassing a spectrum ranging from indolent cutaneous to malignant and systemic conditions. Bullous mastocytosis is a rare cutaneous form. Case characteristics: A male infant with recurring bullous ...

Giant bullous emphysema, or vanishing lung syndrome, typically occurs in young, thin male smokers with large bullae in one or more upper lobes occupying at least one-third of the hemithorax. We present here a rare case of giant bullous emphysema in a mid-age nonsmoking female who was seen for progressive shortness of breath and cough. Chest computed tomography found a giant bulla in the middle ...

LABD: Linear IgA bullous dermatosis INTRODUCTION Linear IgA bullous dermatosis (LABD) is a rare disorder characterized by tense bullae arranged annularly on the trunk and extremities. LABD is usually idiopathic or associated with medications, classically vancomycin and nonsteroidal anti-inflammatory drugs. Rarely, LABD has been reported in association with lymphoproliferative disorders, sarcoma...