Nagarmotha roots were obtained from a local dealer of Ayurvedic medicines, identified and a suspension containing 80 mgiml of the drug '\as prepared in ion free distilled water using gum acasia as suspending agent. Healtr.y pigeons weighing between 200-300 g were divided into four groups of 10 each. They were fed with grain (Jwar) in the morning and the experiments were performed at II a.m. Gro...

Purpose: To develop a simple, rapid and improved colorimetric method for the assay of reserpine in tablets Method: The method is based on the aromatic ring coupling of reserpine with 4-carboxyl-2,6dinitrobenzene diazonium ion with the consequent formation of an azo adduct. Optimization of reaction conditions and validation were carried out and the method applied to assay of reserpine in tablets...

Adult Syrian hamsters were given a subcutaneous injection of reserpine 3 days before an intraperitoneal injection of (3)H-3,4 dihydroxyphenylalanine or (3)H-5, hydroxytryptophan and the carotid bodies were subsequently prepared for electron microscopic radioautography. Other Syrian hamsters were given a subcutaneous injection of reserpine and the carotid bodies were subjected to a sensitive cyt...

Recent reports on the efficacy of pharmacological management in reducing mortality associated with mild hypertension have enhanced the importance of increasing our knowledge about drug toxicity. The Hypertension Detection and Follow-Up Program (HDFP) provides a convenient setting in which to examine the association reported between reserpine usage and breast cancer. In the intensively treated a...

Individuals are known to differ in their sensitivity to cocaine. Cocaine is known to inhibit the re-uptake of monoamines. The response to cocaine has also been found to depend on monoamines inside reserpine-sensitive storage vesicles. The present study examined the effects of reserpine (1-2 mg/kg) on cocaine-induced behavior (10-15 mg/kg) in Low Responders (LR) and High Responders (HR) to novel...

Since antiretroviral drugs are known to inhibit many cytochrome P450 isoforms, the inhibition of CYP2B6 by non-nucleoside reverse transcriptase inhibitors and viral protease inhibitors was studied in vitro in human liver microsomes using bupropion hydroxylation as the CYP2B6 index reaction. Mean IC(50) values (microM) for inhibition of bupropion hydroxylation were: nelfinavir (2.5), ritonavir (...

The purpose of this paper was to investigate the efficacy of bupropion and varenicline for treating nicotine dependence as reported in the published studies. We analysed 435 journal articles identified in Pubmed data base with “nicotine, dependence, bupropion / varencline” included in abstract. The “human” filter was applied. 20 efficacy studies were selected and included for evaluation in this...