Tributyltin in the concentration range 1-4mum failed to stimulate Ca(2+) transport by Lucilia flight-muscle mitochondria in a medium containing KCl and respiratory substrate but devoid of P(i), despite its promotion of a rapid Cl(-)/OH(-) exchange. When 2mm-P(i) was present, concentrations of tributyltin greater than 1mum inhibited the initial rate of Ca(2+) transport and induced efflux of the ...

Travertine deposits are a kind of continental carbonates that form in specific chemical, physical and biological conditions. Garab travertines in southeast of Mashhad are studied based on field, geochemistry (elemental and stable isotope analysis) and hydro-geochemistry analysis. Field and petrographic characterization led to recognize of crystalline crust, raft, foam, shrub, laminated, black m...

The olfactory system detects small volatile molecules, odorants, which enter the nasal cavity via the inhaled air during normal breathing or sniffing. Odorants bind to odorant receptors (ORs) located on the cilia of olfactory sensory neurons (OSNs). Each OSN expresses only one type of OR from ∼1,000 in the mouse genome. Cilia are embedded in the mucus covering the epithelium and are the site of...

Abstract This study aimed to identify the factors responsible for major ion composition of pore water from bottom sediments Bratsk reservoir, which is part largest freshwater Baikal-Angara system. In overlying was characterized as HCO 3 –Ca–Mg type with mineralization ranging between 101.2 and 127.7 mg L ?1 –SO 4 –Ca, SO –Cl–Ca–Mg mixed types, had varying 165.9 4608.1 . The ionic waters varied ...

Cyclic AMP-activated intestinal Cl- secretion plays an important role in pathogenesis of cholera. This study aimed to investigate the effect of diclofenac on cAMP-activated Cl- secretion, its underlying mechanisms, and possible application in the treatment of cholera. Diclofenac inhibited cAMP-activated Cl- secretion in human intestinal epithelial (T84) cells with IC50 of ∼ 20 µM. The effect re...

(54) SELECTIVE GLYCOSIDASE INHIBITORS Publication Classification AND USES THEREOF 51) Int. Cl. (75) Inventors: Harold G. Selnick, Ambler, PA (US); ( Kun Liu, Edison, NJ (US); Ernest J. C07D 263/58 (2006.01) McEachern, Vancouver (CA); Yuanxi C07D 413/04 (2006.01) Zhou, Richmond (CA); Yongbao Zhu, C07D 417/04 (2006.01) Langley (CA) C07D 277/60 (2006.01) (52) U.S. Cl. (73) Assignees: Alectos Thera...

The generation of an excitatory receptor current in mammalian olfactory sensory neurons (OSNs) involves the sequential activation of two distinct types of ion channels: cAMP-gated Ca(2+)-permeable cation channels and Ca(2+)-gated Cl(-) channels, which conduct a depolarizing Cl(-) efflux. This unusual transduction mechanism requires an outward-directed driving force for Cl(-), established by act...