نتایج جستجو برای: calcium ion
تعداد نتایج: 356648 فیلتر نتایج به سال:
Ion channels are embedded in the lipid bilayer of cell membranes; therefore, it is not surprising that their functions can be modulated by membrane phospholipids and their metabolites. Over the last decade, a number of ion channels—including multiple types of potassium channels, voltage-gated calcium channels, and transient receptor potential channels—have been shown to be modulated by phosphol...
The goal of this work is to determine how GCaMP6m's fluorescence is altered in response to Ca2+-binding. Our detailed spectroscopic study reveals the simplest explanation for how GCaMP6m changes fluorescence in response to Ca2+ is with a four-state model, in which a Ca2+-dependent change of the chromophore protonation state, due to a shift in pKa, is the predominant factor. The pKa shift is qua...
The response of double-helical DNA to torsional stress may be a driving force for many processes acting on DNA. The 1.55-A crystal structure of a duplex DNA oligonucleotide d(CCAGGCCTGG)(2) with an engineered crosslink in the minor groove between the central guanine bases depicts how the duplex can accommodate such torsional stress. We have captured in the same crystal two rather different conf...
Ion channels are embedded in the lipid bilayer of cell membranes; therefore, it is not surprising that their functions can be modulated by membrane phospholipids and their metabolites. Over the last decade, a number of ion channels—including multiple types of potassium channels, voltage-gated calcium channels, and transient receptor potential channels—have been shown to be modulated by phosphol...
The theory of light scattering indicates that aggregation of the crystalline lens proteins can produce opacity. Furthermore, it is known that calcium increase? in the cataractous lens. We have, therefore, investigated the effectiveness of calcium ion in producmg aggregates of the soluble proteins of the bovine lens. The experimental restdts show: (1) CaCU produce's aggregates of the soluble pro...
The effect of pressure on the calcium dependent hydrolysis of para-nitrophenyl phosphate by the calcium transport enzyme of the sarcoplasmic reticulum was studied under different conditions: temperature, solutes, substrate and ion concentrations. The calcium transport enzyme exhibits a large positive activation volume which does neither depend on the enzyme's inhibition by high salt concentrati...
Genetically encoded calcium indicators (GECIs) are mainly represented by two- or one-fluorophore-based sensors. One type of two-fluorophore-based sensor, carrying Opsanus troponin C (TnC) as the Ca2+-binding moiety, has two binding sites for calcium ions, providing a linear response to calcium ions. One-fluorophore-based sensors have four Ca2+-binding sites but are better suited for in vivo exp...
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