Rat odontoblasts were shown to synthesize and secrete gamma-carboxyglutamic acid(Gla)-containing proteins into dentine after organ culture in the presence of radiolabelled amino acid precursors. Purified dentine Gla-containing protein from rat incisors was used as antigen to prepare rabbit antisera as a probe of dentine Gla-containing-protein biosynthesis in organ cultures of dentine (rat incis...

Abstract Biomaterials are routinely used in dentistry for tissue engineering. The purpose of the present work is to compare performance a new alloplastic biomaterial (Blue-Bone®), xenogeneic (Bio-Oss®), and mixture both biomaterials with 50% autogenous bone. 32 Wistar rats underwent surgical procedure which circular disc bone was removed from calvaria trephine drill 10 mm diameter create critic...

background: it has been stated that the bone allografts from different tissue banks may lead to various amount of bone induction, so the aim of this study was to evaluate bone regeneration of three demineralized allografts both histologically and histomorphometrically in rabbits calvaria bone defects. materials and methods: in this double-blind randomized experimental animal study, 32 critical ...

promoted by demineralised bone, reconstituted acid-soluble collagen, and gelatin in the form of Gelfoam.t The index employed was the rate of bone repair in a standard defect produced in the calvaria of rats. These investigations are an extension of our earlier studies in which we observed that, under certain conditions, chondroitin sulphate would restore the mineralising properties of demineral...

Materials and Methods: An 8 mm calvarial defect was created in the athymic rat and filled with either the test article (BLX Putty) or autograft. This model is a well-established and validated model for testing the osteoregenerative capacity of bone substitutes wherein an 8 mm defect in the rat calvaria will not spontaneously heal without treatment. The test article was provided in ready-touse a...