Scavenger receptor class B type I (SR-BI) functions as an HDL receptor that promotes the selective uptake of cholesteryl esters (CEs). The physiological role of SR-BI in VLDL metabolism, however, is largely unknown. SR-BI deficiency resulted in elevated VLDL cholesterol levels, both on chow diet and upon challenge with high-cholesterol diets. To specifically elucidate the role of SR-BI in VLDL ...

The Cu-Bi system exhibits nearly no solubility of Bi in Cu along with the highest solute boundary enrichment factor among metal systems making the Cu-Bi system ideal for segregation studies [1]. Cu-Bi also shows a high degree of segregation induced grain boundary embrittlement. The precise cause of this embrittlement has been attributed to Bi size effects along the Cu boundary or modification o...

Safety, tolerability and pharmacokinetics of BI 409306, a potent and selective phosphodiesterase 9A inhibitor, were assessed in healthy subjects in three Phase I, within-dose group, double-blind trials. Trial 1 randomised young and elderly subjects to receive BI 409306 25, 50, 100 mg, placebo once daily (OD) or BI 409306 50 mg twice daily (young) for 14 days. Trial 2 randomised young poor metab...

This study examined the specificity of disgust in predicting avoidance in blood/injury (BI) phobia. Participants high (n=38) and low (n=46) in BI fear completed measures of disgust across multiple domains and severity of BI-related fear. They then completed three randomly presented behavioral avoidance tasks (BATs) that consisted of exposure to a 15'' severed deer leg (BI task), a live spider (...

OBJECTIVE The high-density lipoprotein (HDL) receptor scavenger receptor Class B type I (SR-BI) plays a key role in mediating the final step of reverse cholesterol transport. This study examined the possible regulation of hepatic SR-BI by phosphatidylinositol-3-kinase (PI3K), a well known regulator of endocytosis and membrane protein trafficking. METHODS AND RESULTS SR-BI-dependent HDL select...

Users of Business Intelligence (BI) systems have started to demand more flexible systems in which they could be empowered to serve themselves – self-service BI. In this paper we aim at explaining how such development influences designers of BI solutions and how it impacts the design situation. To say something about this we adapted the PACT (People, Activity, Context, Technology) framework on t...

BACKGROUND While brief intervention (BI) for risky alcohol use generally yields positive effects among those identified by screening, effect sizes are small and there is unexplained heterogeneity in outcome. The heterogeneity may be related to differences in intervention style and content, including elements of motivational interviewing (MI). To date, it has been difficult to interpret the role...

Business intelligence (BI) combined with business analytics (BA) is an increasingly prominent strategic objective for many organizations. As a pedagogical subject, BI/BA is still in its infancy, and, in order for this to mature, we need to develop an undergraduate model BI/BA curriculum. BI/BA as an academic domain is emerging as a hybrid of disciplines, including information systems, statistic...

Advanced glycation end products (AGE) -modified proteins behave as active ligands for several receptors belonging to the scavenger receptor family. Scavenger receptor class B type I (SR-BI) was identified as the first high density lipoprotein (HDL) receptor that mediates selective uptake of HDL-cholesteryl esters (HDL-CE). This study investigated whether AGE proteins serve as ligands for SR-BI ...