Transcriptional targeting is the best approach for specific gene therapy. Hypoxia is a common feature of the tumour microenvironment. Therefore, targeting gene expression in hypoxic cells by placing transgene under the control of a hypoxia-responsive promoter can be a good strategy for cancer-specific gene therapy. The hypoxia-inducible gene expression system has been investigated more in suici...

background: the fundamental principles of internal targeted alpha therapy for cancer were established many decades ago.the high linear energy transfer (let) of alpha radiation to the targeted cancer cellscauses double strand breaks in dna. at the same time, the short range radiation spares adjacent normal tissues. this targeted approach complements conventional external beam radiotherapy and ch...

Gene Therapy In article 2202358, Minseok Kwak, Peter Chang-Whan Lee, and co-workers show effective tumor suppression using RNAi with just three DNA RNA strands. This transfection reagent-free technique self-assembles siRNAs covers micelles to create nanomedicine for lung cancer. Raw data files are used a montage background, recognizing the work of graduate students.

background: colorectal cancer, the third most common type of cancer is a major cause of mortality worldwide. if colorectal cancer is detected at the early stages, the 5-year survival rate is 90%. meis1 homeobox gene is implicated in numerous solid tumors and hematological malignancies. therefore, the present study aims to investigate the methylation status of the meis1 gene in colorectal cancer...

conclusions over-expression of the synthetic cpc/β protein in the bacterial system (escherichia coli bl-21) showed that e. coli can be used as a basis for further research to produce this desired protein in large quantities. results the sds-page analysis and dot blotting confirmed the production of recombinant c-pc/β in the bacterial expression system. over-expression of cpcb gene was optimized...

Epithelial ovarian cancer is the second most common malignancy of female genital tract, with approximately 7,400 new cases annually in Germany. With 5,500 deaths per year, leading gynecologic cause death. characterized by morphologic heterogeneity 4 molecular biological subtypes (immunoreactive-like, differentiated-like, proliferative-like, mesenchymal-like) different prognosis. Significantly i...

− New treatment approaches are needed to improve the effectiveness of oral cancer treatment, since surgical resection of the tumor in oral region causes various oral dysfunctions. The molecular biology of oral cancer has been progressively delineated. Concurrently, gene therapy techniques have been developed that allow targeting or replacement of dysfunctional genes in cancer cells, offering th...

Cancer is an unusual development of cells the proximate reason for which is unevenness in cell expansion and demise getting through the ordinary physiological governing rules framework and a definitive reason for which are one or even more an assortment of quality adjustments. These modifications can be basic, e.g. transformations, insertions, erasures, intensifications, combinations and transl...