BACKGROUND Astrocytes and metabotropic glutamate receptors play important roles in nociceptive processing. However, their roles in bone cancer pain were not well understood. This study sought to investigate whether selective mGluR3 and mGluR5 agonist or antagonist develop antinociceptive effects on bone cancer pain by inhibition of spinal astrocyte activation. METHODS C3H/HeNCrlVr mice were i...

This literature review explores the effectiveness of massage therapy to reduce cancer pain. As part of the review, systematic literature search was carried out on various electronic databases and specialised journals. Included are 19 research-based articles and 8 review articles. The review suggests that cancer has become a common health problem in the world and most of the cancer patients are ...

The undertreatment of cancer pain remains a significant clinical problem. Of note, large variability exists in pain among individuals. inadequately controlled pain results in unnecessary suffering and a diminished ability to tolerate primary cancer therapy. new drug formulations and delivery systems are under development, and new approaches are required to individualize pain management. Oncolog...

BACKGROUND: The high prevalence of cancer pain shows that a lot the patients are undertreatment. Vitamin B is one additional alternative substances studied in management. Thiamine believed to modulate mechanisms lowering Cathecol-O-Methyltransferase (COMT) enzyme level. AIM: aim study was assess correlation between Oral as an Opioid Adjuvant and COMT Enzyme Levels Cervical Cancer Patients METHO...

Pain treatment is a critical aspect of pancreatic cancer patient clinical care. This study investigated the role of trypsin-protease activated receptor-2 (PAR-2) in pancreatic cancer pain. Pancreatic tissue samples were collected from pancreatic cancer (n=22) and control patients (n=22). Immunofluorescence analyses confirmed colocalization of PAR-2 and neuronal markers in pancreatic cancer tiss...

The aim of the present study is to find out the influence of rational-emotive behavior therapy (REBT) on pain intensity among cancer patients in India and Iran. The study followed a quasi-experimental, pre-post test, carried out with a sample of 88 cancer patients, aged 21-52 years, referred to the Baharat cancer hospital of Mysore in India and Shahidzade hospital of Behbahan in Iran. They were...

Copyright © 2016 Xue-Jun Song et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Cancer pain possesses a major challenge in clinical treatment , yet its underlying mechanisms remain elusive. Recent advances in understanding th...

BACKGROUND Pain in advanced cancer is complex and multifaceted. In older patients comorbidities and age-related functional decline add to the difficulties in managing cancer pain. The current emphasis on care in the community, and preference by patients with life-limiting disease to receive care in the home, has meant that patients and their family caregivers have become increasingly responsibl...

BACKGROUND Although pain affects the quality of life of cancer patients, current medical treatments are either ineffective or have side effects. In the present study we investigated the effect of electroacupuncture (EA) on cancer-induced hyperalgesia and expression of interleukin-1beta (IL-1beta), upregulation of which is related to the maintenance of persistent pain, in a rat model of bone can...

Pain is a common and devastating symptom of cancer that can be effectively controlled with currently available pharmacological and non-pharmacological therapies. Unfortunately, there continue to be reports that half of patients with cancer have inadequate relief of their pain with devastating effects on their quality of life and functional status. Systematic efforts to understand and eliminate ...