OBJECTIVES Although azole antifungals are considered to be fungistatic, miconazole has fungicidal activity against planktonic Candida albicans cells, presumably associated with the induction of reactive oxygen species (ROS) production. Only few data are available concerning the effect of miconazole against sessile C. albicans cells. In the present study, the fungicidal activity of miconazole ag...

OBJECTIVE To determine the proportion of albicans and non-albicans candiduria in a hospital setting and to ascertain if fluconazole is still suitable as empirical antifungal therapy based on antifungal susceptibility patterns of Candida species. METHODS The cross-sectional study was conducted between December 2010 and December 2011 at UKM Medical Centre, Kuala Lumpur, Malaysia and comprised 6...

denture stomatotos os a common problem of the denture wears, and it's etiology is not clear from the literatures. some studies show that the aetiology is candida albicans, while other reports point out the other agents including candida albicans. the present study was designed to evaluate the prevalence of oral candidiasis in patients using complete denture with different datas. 50 subject...

vulvovaginal candidiasis is caused by the increasing number of candida species as normal flora in the vagina. to assess the transmission rout as well as to determine the suitable antifungal drugs for treatment, the exact identification of candida species is crucial. therefore, earlier detection of infection allows quick initiation of antifungal therapy with a greater probability for improved su...

background vaginitis is the most common gynecological problem and the second most common infection. this condition occurs in approximately 90% of the affected females; secondary to bacterial vaginosis and vulvovaginal candidiasis. objectives according to the high prevalence of vulvovaginal candidiasis in iran and because of the importance of controlling causing species, the current study aimed ...

objective(s) the fractions of candida albicans have been used as an immunomodulator. the present work assessed the effect of different fractions of c. albicans on nitric oxide (no) production by mice peritoneal macrophages. materials and methods cell wall and cytoplasmic fractions of c. albicans atcc 10321 strain were extracted. mice peritoneal macrophages were purified and cultured. different ...

virulence of the opportunistic yeast, candida albieans, involves the interplay of many complex changes including the yeast-hyphae transition, which mainly involves protein changes. cell wall mannoproteins are found to be the main cause of adherence of c. albieans to epithel ial cells in the first step of an infection process. in the present study, cell wall mannoproteins of intact yeast were pu...

Non-Candida albicans Candida species are increasingly being isolated. These species show differences in levels of resistance to antimycotic agents and mortality. Therefore, it is important to be able to correctly identify the causative organism to the species level. Identification of C. dubliniensis in particular remains problematic due to the high degree of phenotypic similarity between this s...

Twelve Spanish laboratories collected 325 yeast clinical isolates during a 30 day's period, among them 224 Candida albicans, 30 Candida glabrata, and 27 Candida parapsilosis. In vitro antifungal susceptibility to amphotericin B, ketoconazole, fluconazole and itraconazole was determined by an agar diffusion test (Neo-Sensitabs, Rosco, Denmark). All the isolates tested were susceptible in vitroto...

The incidence of candidemia--a common and potentially fatal nosocomial infection--has risen dramatically, and this increase has been accompanied by a shift in the infecting pathogen away from Candida albicans to treatment-resistant non-albicans species. Prophylactic azole antifungals, such as fluconazole, may play an important role not only in the management of candidemia but also in the prolif...