background: iranian (lahijan) black tea caffeine has been previously shown to have antifungal activity against candida albicans. the aim of this study was to investigate whether the combination of caffeine and fluconazole (flu) has an effective antifungal activity on a flu-resistant (mic >64mgl-1) c. albicans ptcc5027. materials and methods: caffeine from lahijan black tea was extracted and its...

background: the most important virulence factor which plays a central role in candida albicans pathogenesis is the ability of this yeast to alternate between unicellular yeast and filamentous hyphal forms. efg1 protein is thought to be the main positive regulating transcription factor, which is responsible for regulating hyphal-specific gene expression under most conditions. als3 is one of the ...

introduction: the aim of this study was to evaluate the effect of dentin on the antifungal activity of gray and white-colored mta (gmta, wmta) using a tube-dilution test. materials and methods: mta preparations were tested freshly mixed and after 24h on candida albicans (ca). the experiment was performed in 24-well culture plates. fifty wells were used and divided into four experimental groups ...

the opportunistic pathogen c.albicans is able to cause disseminated infections in immunocompromised patients. microbiological methods for the diagnosis of invasive candidiasis have many problems including low sensitivity, requirement to invasive clinical sampling such as biopsies or multiple blood cultures and need to expertise laboratory stuff. since pcr has proven to be a powerful tool in the...

background the ability of candida albicans to form biofilms and adhere to host tissues and biomaterial surfaces is an important factor in its pathogenesis. one of the main characteristics of biofilms is their resistance to broad-spectrum anti-microbial drugs. objectives in the present study the formation of biofilm by c. albicans from different sources was evaluated. in addition, the minimum bi...

BACKGROUND Candida spp. is frequently isolated from cases of vulvovaginal candidiasis and catheter associated UTI. C.albicans is the most frequently isolated species but non-albicans species of candida are gaining clinical significance. OBJECTIVES To compare the virulence factors like biofilm production, phospholipase and hemolytic activity in C.albicans with that of non albicans species of c...

OBJECTIVE To determine the oral status, salivary flow rate, Candida carriage in saliva, and prevalence of Candida albicans colonization in several areas of the mouth in patients with primary and secondary Sjögren's syndrome as opposed to those of healthy subjects. STUDY DESIGN Thirty-seven patients with Sjögren's syndrome (SS), [14 patients with primary SS (SS-1) and 23 patients with secondar...

PURPOSE To study contents of atherosclerotic plaques for the presence of fungi of the genus Candida; and an analysis of some immunological and biochemical indices in patients with acute coronary syndrome (ACS) that are positive for Candida albicans. MATERIALS AND METHODS To test for the presence of fungi in an atherosclerotic plaque, we used a method developed by us (patent NO 531, a priority...

Background and Purpose: Oropharyngeal candidiasis (OPC) and antifungal drug resistance are major health concerns in patients with human immunodeficiency virus (HIV). The increased reports of antifungal resistance and expanding drug therapy options prompted the determination of antifungal susceptibility profile. The present study was performed to determine the antifungal susceptibility of Candid...